Karyotype and DNA-Methylation Responses in Myelodysplastic Syndromes following Treatment with Traditional Chinese Formula Containing Arsenic

Table 5

Pathways of hypermethylated genes after treatment.

Path_id	Path_name	diffgene_count	P value	FDR
10	Glycolysis / Gluconeogenesis	4	5.97𝐸−03	3.82𝐸−02
4622	RIG-I-like receptor signaling pathway	4	8.21𝐸−03	3.82𝐸−02
5164	Influenza A	6	1.09𝐸−02	3.82𝐸−02
5215	Prostate cancer	4	1.82𝐸−02	4.34𝐸−02
4666	Fc gamma R-mediated phagocytosis	4	2.35𝐸−02	4.56𝐸−02
5131	Shigellosis	3	3.68𝐸−02	4.85𝐸−02
4964	Proximal tubule bicarbonate reclamation	2	3.71𝐸−02	4.85𝐸−02
5120	Epithelial cell signaling in Helicobacter pylori infection	3	4.90𝐸−02	4.99𝐸−02

This table shows pathways of hypermethylated genes after treatment. Path_id: gene ID number in KEGG database; Path_name: pathway of gene; diffgene_count: number of gene methylated in specific pathway; 𝑃 value: 𝑃<0.01 indicating methylation is significant; FDR: false discovery rate, 𝑃<0.05 as filter cutoff rate.