Review Article

Cancer-Related Stress and Complementary and Alternative Medicine: A Review

Figure 1

Overview of the hypothalamus-pituitary-adrenal axis in relation to the stress response in healthy individuals (a) and those with cancer (b). CRH: corticotrophin-releasing hormone; ACTH: adrenocorticotropic hormone. Thin dashed lines represent reduced feedback inhibition.
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(a) Normal HPA-axis regulation
979213.fig.001b
(b) Proposed HPA-axis dysregulation for high cortisol levels