Research Article
Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds
Table 2
Screening of Chinese herbal medicines for agonistic activity towards PPARα and PPARγ and inhibition of TNF-α-induced NF-κB activity in vitro. PE = petroleum ether, EtOAc = ethyl acetate, MeOH = methanol. Dry material from all test samples was dissolved in DMSO at a concentration of 10 mg/mL and tested at a final concentration of 10 μg/mL. Regarding PPARs: no activation compared to control (0.1% DMSO): −; 1.5- to 2-fold activity compared to control (): +; more than 2-fold of the control (): ++. Regarding NF-κB: inhibition in the range of 0–50% compared to the vehicle-treated control (0.1% DMSO): −; 50–80% inhibition (): +; over 80% inhibition (): ++. At least three independent experiments were performed with every sample, and statistical analysis was performed by ANOVA.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||