Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin
Table 2
Metabolism and ischemic injury of mice after 4 weeks of diet exposure.
After 4 weeks of diet exposure
Con
HF
HF2WCA2W
HF2WMET2W
Body weight (g)
35.5 0.8
40.2 1.0*
39.7 1.2*
38.3 0.7*
Plasma insulin (pM)
117.58.8
203.521.1*
148.3 29.2#
131.1 20.5#
Plasma glucose during IPGTT (mg/dL)
0 min after injection
109.2 7.5
169.9 4.5*
149 6.9*,#
151.4 8.5*, #
30 min after injection
290.8 31.5
359.0 17.5*
291.7 2.4*, #
271.8 2.3*, #
120 min after injection
172.2 26.3
297.5 20.5*
166.7 10.2*, #
179.3 5.2*, #
Basal coronary flow (mL/min)
3.4 0.5
1.6 0.3*
3.6 0.4#
2.5 0.4#
Infarct size of the heart after global ischemia/reperfusion (AAR%)
30.6 5.1
39.4 6.6*
29.9 4.8#
30.0 3.8#
CAPA was introduced after 2 weeks of diet exposure and orally treated once a day for another 2 weeks. Con: control mice; HF: mice fed with high fat and diet; HF2WCA2W: HF mice treated with CAPA for another 2 weeks; HF2WMET2W: HF mice treated with metformin for another 2 weeks; AAR: area at risk; *: P <0.05 versus Con; #: P <0.05 versus HF; n = 6–8 per group.