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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 985457, 10 pages
doi:10.1155/2012/985457
Research Article
Effects of the Yangjing Capsule Extract on Steroidogenesis and Apoptosis in Mouse Leydig Cells
1Institute of Andrology, Nanjing University of Chinese Medicine, Nanjing 210046, China
2State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, and the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
Received 12 May 2012; Revised 4 September 2012; Accepted 3 October 2012
Academic Editor: Cheppail Ramachandran
Copyright © 2012 Dalin Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- E. J. Richmond and A. D. Rogol, “Male pubertal development and the role of androgen therapy,” Nature Clinical Practice Endocrinology and Metabolism, vol. 3, no. 4, pp. 338–344, 2007. View at Publisher · View at Google Scholar · View at Scopus
- M. R. Pinsky and W. J. G. Hellstrom, “Hypogonadism, ADAM, and hormone replacement,” Therapeutic Advances in Urology, vol. 2, no. 3, pp. 99–104, 2010. View at Publisher · View at Google Scholar · View at Scopus
- M. Rabijewski and W. Zgliczyński, “Pathogenesis, evaluation and treatment of hypogonadism in men,” Endokrynologia Polska, vol. 60, no. 3, pp. 222–233, 2009. View at Scopus
- N. Bassil, S. Alkaade, and J. E. Morley, “The benefits and risks of testosterone replacement therapy: a review,” Therapeutics and Clinical Risk Management, vol. 5, no. 1, pp. 427–448, 2009. View at Scopus
- S. Kliesch, “Testosterone and infertility,” Der Urologe A, vol. 49, no. 1, pp. 32–36, 2010. View at Publisher · View at Google Scholar · View at Scopus
- W. G. Ma and J. M. Jia, “The effects and prospects of the integration of traditional Chinese medicine and Western medicine on andrology in China,” Asian Journal of Andrology, vol. 13, no. 4, pp. 592–595, 2011. View at Publisher · View at Google Scholar · View at Scopus
- H. Q. Jin, F. Jiang, D. M. Deng, W. X. Chen, G. Z. Yang, and T. Q. Zhuang, “Regulatory effect of Bushenfang on the serum testosterone level of naturally aging rats and its mechanism,” Zhonghua Nan Ke Xue, vol. 17, no. 8, pp. 758–762, 2011.
- B. F. Jin, Y. F. Huang, and X. H. Lu, “Clinical observation of the treatment of male sexual dysfunction by yangjingjiaonang,” Zhonghua Nan Ke Xue, vol. 12, no. 3, pp. 272–276, 2006. View at Scopus
- B. F. Jin, Y. F. Huang, X. Y. Yang, X. J. Shang, X. H. Lu, and X. L. Wang, “Clinical observation on treatment of oligosperntatisn with yangjing capsule,” Journal of Nanjing TCM University, vol. 22, no. 5, pp. 286–289, 2006.
- B. Jin, Y. Huang, X. Xia, X. Wang, X. Yang, and Z. Zhou, “Effect of Yangjing capsule and Xinxibao on sperm DNA integrity of patients with male infertility,” Chinese Journal of Andrology, vol. 20, no. 12, pp. 45–49, 2006. View at Scopus
- M. L. Dufau, “Endocrine regulation and communicating functions of the Leydig cell,” Annual Review of Physiology, vol. 50, pp. 483–508, 1988. View at Scopus
- S. G. Haider, “Leydig cell steroidogenesis: unmasking the functional importance of mitochondria,” Endocrinology, vol. 148, no. 6, pp. 2581–2582, 2007. View at Publisher · View at Google Scholar · View at Scopus
- K. Henriksen, H. Hakovirta, and M. Parvinen, “Testosterone inhibits and induces apoptosis in rat seminiferous tubules in a stage-specific manner: in situ quantification in squash preparations after administration of ethane dimethane sulfonate,” Endocrinology, vol. 136, no. 8, pp. 3285–3291, 1995. View at Scopus
- M. A. Helal, H. Mehmet, N. S. B. Thomas et al., “Ontogeny of human fetal testicular apoptosis during first, second, and third trimesters of pregnancy,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 3, pp. 1189–1193, 2002. View at Publisher · View at Google Scholar · View at Scopus
- I. Budihardjo, H. Oliver, M. Lutter, X. Luo, and X. Wang, “Biochemical pathways of caspase activation during apoptosis,” Annual Review of Cell and Developmental Biology, vol. 15, pp. 269–290, 1999. View at Publisher · View at Google Scholar · View at Scopus
- P. Saikumar, Z. Dong, V. Mikhailov, M. Denton, J. M. Weinberg, and M. A. Venkatachalam, “Apoptosis: definition, mechanisms, and relevance to disease,” American Journal of Medicine, vol. 107, no. 5, pp. 489–506, 1999. View at Publisher · View at Google Scholar · View at Scopus
- S. T. Kao, C. C. Yeh, C. C. Hsieh et al., “The Chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest,” Life Sciences, vol. 69, no. 13, pp. 1485–1496, 2001. View at Publisher · View at Google Scholar · View at Scopus
- B. Hu, H. M. An, K. P. Shen, and Q. Du, “Effects of Tenglong Buzhong Decoction on proliferation and apoptosis of human colon carcinoma cell line LS174T,” Zhong Xi Yi Jie He Xue Bao, vol. 8, no. 6, pp. 575–580, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Y. Wang, L. Song, X. Hong et al., “Low concentrations mono-butyl phthalate stimulates steroidogenesis by facilitating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1),” Chemico-Biological Interactions, vol. 164, no. 1-2, pp. 15–24, 2006. View at Publisher · View at Google Scholar · View at Scopus
- Y. Fu, Z. Zhang, G. Zhang et al., “Adenovirus-mediated gene transfer of tissue factor pathway inhibitor induces apoptosis in vascular smooth muscle cells,” Apoptosis, vol. 13, no. 5, pp. 634–640, 2008. View at Publisher · View at Google Scholar · View at Scopus
- S. Abid-Essefi, I. Baudrimont, W. Hassen et al., “DNA fragmentation, apoptosis and cell cycle arrest induced by zearalenone in cultured DOK, Vero and Caco-2 cells: prevention by Vitamin E,” Toxicology, vol. 192, no. 2-3, pp. 237–248, 2003. View at Publisher · View at Google Scholar · View at Scopus
- A. R. Doo, S. N. Kim, J. Y. Park et al., “Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+/MPTP-induced cytotoxicity in vitro and in vivo,” Journal of Ethnopharmacology, vol. 131, no. 2, pp. 433–442, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Z. Quan and J. Wei, “The research of traditional Chinese drug kidney-reinforcing on increasing testosterone level-based on Meta analysis of 7 clinical contrast experiments,” Medical Information, vol. 18, no. 9, pp. 1153–1155, 2005.
- P. Pigny, A. Berault, D. Dewailly, and A. Boersma, “Glycoprotein hormones, glycosylation and biological activity,” Annales de Biologie Clinique, vol. 50, no. 8, pp. 557–564, 1992. View at Scopus
- E. Ruoslahti, “Proteoglycans in cell regulation,” Journal of Biological Chemistry, vol. 264, no. 23, pp. 13369–13372, 1989. View at Scopus
- A. J. Lapthorn, D. C. Harris, A. Littlejohn et al., “Crystal structure of human chorionic gonadotropin,” Nature, vol. 369, no. 6480, pp. 455–461, 1994. View at Publisher · View at Google Scholar · View at Scopus
- Z. B. Zhang and Q. T. Yang, “The testosterone mimetic properties of icariin,” Asian Journal of Andrology, vol. 8, no. 5, pp. 601–605, 2006. View at Publisher · View at Google Scholar · View at Scopus
- Y. Zhou and Y. Geng, “Study on relationship between polysaccharides and cell apoptosis,” Chinese Traditional and Herbal Drugs, vol. 38, no. 4, pp. 623–626, 2007. View at Scopus
- Q. M. Liu and J. G. Jiang, “Antioxidative activities of medicinal plants from TCM,” Mini-Reviews in Medicinal Chemistry, vol. 12, no. 11, pp. 1154–1172, 2012. View at Publisher · View at Google Scholar
- G. Z. Hu, R. Q. Nie, Y. S. Xiao, J. Zhang, Z. Wen, and D. F. Wu, “Influence of polygonatum polysaccharide on apoptosis of primary cultured neonate rat cerebral cortical neurons caused by hypoxia,” Pharmacology and Clinics of Chinese Materia Medica, vol. 21, no. 4, pp. 37–39, 2005.
- M. S. Miao, Y. H. Sun, and X. Y. Fang, “Studies on anti-axidation capacity of radix rehmaniae preparate polysaccharide in aged model mice,” Chinese Journal of Information on Traditional Chinese Medicine, vol. 9, no. 10, pp. 32–33, 2002.
- Y. Cui, “The progress in pharmacological research of rchmannia glutnosa polysaccharides,” Chinese Journal of Natural Medicines, vol. 2, no. 3, pp. 186–188, 2000.
- F. Kong, M. Zhang, S. Liao, S. Yu, J. Chi, and Z. Wei, “Antioxidant activity of polysaccharide-enriched fractions extracted from pulp tissue of litchi chinensis sonn,” Molecules, vol. 15, no. 4, pp. 2152–2165, 2010. View at Publisher · View at Google Scholar · View at Scopus
- L. Chang, J. Li, F. Y. Meng et al., “Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway,” BMC Complementary and Alternative Medicine, vol. 10, article 79, 2010. View at Publisher · View at Google Scholar · View at Scopus
- S. W. J. Lamberts, A. W. Van Den Beld, and A. J. Van Der Lely, “The endocrinology of aging,” Science, vol. 278, no. 5337, pp. 419–424, 1997. View at Publisher · View at Google Scholar · View at Scopus
- S. G. Haider, “Cell Biology of Leydig Cells in the Testis,” International Review of Cytology, vol. 233, pp. 181–241, 2004. View at Publisher · View at Google Scholar · View at Scopus
- F. Matsuda-Minehata, N. Inoue, Y. Goto, and N. Manabe, “The regulation of ovarian granulosa cell death by pro- and anti-apoptotic molecules,” Journal of Reproduction and Development, vol. 52, no. 6, pp. 695–705, 2006. View at Publisher · View at Google Scholar · View at Scopus
- A. G. Porter and R. U. Jänicke, “Emerging roles of caspase-3 in apoptosis,” Cell Death and Differentiation, vol. 6, no. 2, pp. 99–104, 1999. View at Scopus