Fermented Wheat Germ Extract Induced Cell Death and Enhanced Cytotoxicity of Cisplatin and 5-Fluorouracil on Human Hepatocellular Carcinoma Cells

Table 1

The half maximal inhibitory concentration (IC₅₀) of FWGE calculated in human HCC cells. IC₅₀ were determined following treatment with FWGE alone or combined with chemotherapeutic drugs by MTT assay after 72 hr.

	HepG2		Hep3B		HepJ5
FWGE (mg/mL)	0.494		0.371		1.524
	Combination of FWGE (mg/mL)
	0	0.5	0	0.25	0	1
Cisplatin (μM)	6.843	1.049	4.436	1.111	15.785	6.021
5-Fu (μM)	5.237	4.591	14.427	15.306	>500	70.571