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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 124747, 19 pages
http://dx.doi.org/10.1155/2013/124747
Research Article

Baicalein Triggers Mitochondria-Mediated Apoptosis and Enhances the Antileukemic Effect of Vincristine in Childhood Acute Lymphoblastic Leukemia CCRF-CEM Cells

1Department of Child Care, College of Humanities and Social Sciences, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan
2Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
3Department of Dermatology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
4Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
5Institute of Biomedical Sciences, College of Life Science, National Chung Hsing University, Taichung, Taiwan
6Department of Medical Research and Education, Taichung Veterans General Hospital, Taichung, Taiwan
7Department of Forestry, National Chung Hsing University, Taichung, Taiwan
8Department of Food Science, National Pingtung University of Science and Technology, Pingtung, Taiwan

Received 15 August 2012; Revised 29 October 2012; Accepted 5 November 2012

Academic Editor: Youn Chul Kim

Copyright © 2013 Yun-Ju Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The combined therapeutic efficacy of baicalein with another commonly used chemotherapeutic drug methotrexate in CCRF-CEM cells. (a) 4×104 cells/well were seeded onto 24-well culture plates, followed by incubation with the indicated doses of baicalein, methotrexate or both for 24 h. The cell viability was determined by the MTT assay. The data are presented as the mean ± SD from triplicate wells. Similar results were obtained in two independent experiments.

  1. Supplementary Material