Role of Garlic Usage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Table 1

Effects of garlic on lipid levels.

Study	Type	Target	Duration of Rx	Dose	Case/control	Outcome
Mader, (1990) [20]	Randomized, placebo-controlled trial	Hyperlipidemic	12 weeks	800 mg garlic powder	130/131	Dec in T. chol level—12%, TG level—17%
Gadkari and Joshi, (1991) [27]	Randomized control trial	Normal individuals	2 months	10 gm of raw garlic	25/25	Dec T. chol, increase clotting time, and fibrinolytic activity
Rotzsch et al., (1992) [31]	Randomized, placebo-controlled, double-blind trial	Healthy individuals with low HDL	6 weeks	900 mg garlic powder	12/12	Dec TG levels and increase HDL levels
Saradeth et al., (1994) [26]	Randomized double-blind study, placebo-controlled trial	Healthy individuals with normal lipid levels	15 weeks	600 mg dried garlic powder	34/34	T. chol dec from 223 to 214 mg/dL; TG dec from 124 to 118 mg/dL
Steiner et al., (1996) [29]	Double-blind crossover trial	Hyperlipidemic	11 months	7.2 g aged garlic	20/21	Dec T. chol 6.1%, dec LDL 4%, systolic BP 5.5% dec, and modest dec in diastolic Bp noticed
Isaacsohn et al., (1998) [38]	Randomized, double-blind, placebo-control trial	Hyperlipidemic	12 weeks	900 mg garlic powder (Kwai)	28/22	No change in lipid levels noticed
Berthold et al., (1998) [39]	Double-blind, randomized, placebo-controlled trial	Hyperlipidemic	12 weeks	10 mg garlic oil	12/13	No change in lipids or lipoproteins levels noticed
Satitvipawee et al., (2003) [37]	Randomized, double-blind, placebo-controlled trial	Hyperlipidemic	4 weeks/12 weeks	Garlic extract	70/76	No dec in T. chol, DL, TG, and HDL levels noticed
Mahmoodi et al., (2006) [30]	Clinical trial	Hyperlipidemic	42 days	Raw garlic 5 gm twice daily	30	Dec T. chol, dec LDL, dec TG, increase HDL level; Reversed after stopping of garlic
Sobenin et al., (2008) [28]	Double blinded placebo controlled	Hyperlipidemic	12 weeks	Allicor; (600 mg daily)	21/21	T. chol 7.6% dec, LDL 11.8%, and HDL inc 11.5%

T. chol: total cholesterol, HDL: high-density lipoprotein, TG: triglyceride, LDL: low-density lipoprotein, and VLDL: very low-density lipoprotein.