Cardiovascular Protective Effects of Adjunctive Alternative Medicine (Salvia miltiorrhiza and Pueraria lobata) in High-Risk Hypertension

Table 2

Changes in clinical and vascular parameters after 12 months.

	Placebo (𝑛=29)		D&G (1 gm/day) (𝑛=31)		D&G (2 gm/day) (𝑛=30)
	Baseline	12 months	Baseline	12 months	Baseline	12 months
SBP (mmHg)	124.4±17.8	136.0±24.0	132.3±13.5	127.3±11.0	134.9±18.8	140.3±14.6
DBP (mmHg)	78.7±13.7	81.90±12.50	88.0±7.6	84.1±8.3	82.9±11.0	84.4±7.1
TC (mmol/L)	4.8±0.9	4.7±1.0	5.4±1.1	5.1±1.0	5.2±0.9	5.0±0.9
TG (mmol/L)	2.0±1.4	2.0±1.5	2.2±1.7	1.8±1.3	1.7±0.8	1.6±0.9
HBA1C (%)	7.5±2.6	7.3±2.1	6.8±2.0	7.0±2.4	6.4±1.0	6.6±0.9
Creatinine (mol/L)	110.0±40.6	109.4±50.3	127.9±58.0	130.0±64.0	110.1±49.3	110.4±83.2
Reactive hyperemia (%)	543±192	485±105	615±208	606±154	535±206	505±133
FMD (%)	5.5±1.3	6.2±1.1^∗	5.4±1.9	7.0±2.1^∗∗	5.0±1.5	6.2±1.6^∗∗
NTG (%)	15.2±2.5	15.9±3.0	18.3±11.9	16.7±3.3	15.4±3.3	16.1±3.1
IMT (mm)	0.80±0.18	0.81±0.17	0.79±0.20	0.74±0.16^∗∗	0.85±0.16	0.82±0.15^∗∗

Compared with baseline within group: ^∗𝑃=0.001;  ^∗∗𝑃<0.0001. SBP: systolic blood pressure, DBP: diastolic blood pressure, TC: total cholesterol, TG: triglyceride, HBA1-C: hemoglobin A1-C, FMD: flow-mediated dilation, NTG: nitroglycerin-induced dilation, and IMT: intima-media thickness, Reactivehyperemia=(velocity−timeintegral₂×heartrate₂)/(velocity−timeintegral₁×heartrate₁)×100.