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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 135314, 17 pages
Sulforaphane Attenuates Gentamicin-Induced Nephrotoxicity: Role of Mitochondrial Protection
1Departamento de Biología, Facultad de Química, UNAM, 04510 Mexico City, DF, Mexico
2Unidad de Investigación en Enfermedades Oncológicas, Hospital Infantil de México “Federico Gómez”, 06720 Mexico City, DF, Mexico
3Sección de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, 14000 Mexico City, DF, Mexico
4Unidad del Bioterio, Facultad de Medicina, UNAM, 04510 Mexico City, DF, Mexico
5Laboratorio de Fisiopatología Renal, Departamento de Nefrología, Instituto Nacional de Cardiología “Ignacio Chávez”, 14080 Mexico City, DF, Mexico
Received 18 December 2012; Revised 16 February 2013; Accepted 19 February 2013
Academic Editor: José Luis Ríos
Copyright © 2013 Mario Negrette-Guzmán et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- C. E. Guerrero-Beltrán, M. Calderón-Oliver, J. Pedraza-Chaverri, and Y. I. Chirino, “Protective effect of sulforaphane against oxidative stress: recent advances,” Experimental and Toxicologic Pathology, vol. 64, no. 5, pp. 503–508, 2012.
- A. T. Dinkova-Kostova and R. V. Kostov, “Glucosinolates and isothiocyanates in health and disease,” Trends in Molecular Medicine, vol. 18, no. 6, pp. 337–347, 2012.
- H. R. Vasanthi, S. Mukherjee, and D. K. Das, “Potential health benefits of broccoli—a chemico-biological overview,” Mini-Reviews in Medicinal Chemistry, vol. 9, no. 6, pp. 749–759, 2009.
- A. T. Dinkova-Kostova and P. Talalay, “Direct and indirect antioxidant properties of inducers of cytoprotective proteins,” Molecular Nutrition and Food Research, vol. 52, supplement 1, pp. S128–S138, 2008.
- L. Gaona-Gaona, E. Molina-Jijón, E. Tapia et al., “Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats,” Toxicology, vol. 286, no. 1–3, pp. 20–27, 2011.
- T. Greco and G. Fiskum, “Brain mitochondria from rats treated with sulforaphane are resistant to redox-regulated permeability transition,” Journal of Bioenergetics and Biomembranes, vol. 42, no. 6, pp. 491–497, 2010.
- T. Greco, J. Shafer, and G. Fiskum, “Sulforaphane inhibits mitochondrial permeability transition and oxidative stress,” Free Radical Biology & Medicine, vol. 51, no. 12, pp. 2164–2171, 2011.
- C. E. Guerrero-Beltrán, M. Calderón-Oliver, E. Martínez-Abundis et al., “Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: quinone oxidoreductase 1 and γ glutamyl cysteine ligase: studies in mitochondria isolated from rat kidney and in LLC-PK1 cells,” Toxicology Letters, vol. 199, no. 1, pp. 80–92, 2010.
- D. K. D. Priya, R. Gayathri, G. R. Gunassekaran, and D. Sakthisekaran, “Protective role of sulforaphane against oxidative stress mediated mitochondrial dysfunction induced by benzo(a)pyrene in female Swiss albino mice,” Pulmonary Pharmacology & Therapeutics, vol. 24, no. 1, pp. 110–117, 2011.
- C. S. Piao, S. Gao, G.-H. Lee et al., “Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels,” Pharmacological Research, vol. 61, no. 4, pp. 342–348, 2010.
- N. Juge, R. F. Mithen, and M. Traka, “Molecular basis for chemoprevention by sulforaphane: a comprehensive review,” Cellular and Molecular Life Sciences, vol. 64, no. 9, pp. 1105–1127, 2007.
- X. Sun, L. Mi, J. Liu, L. Song, F.-L. Chung, and N. Gan, “Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice,” Toxicology and Applied Pharmacology, vol. 255, no. 1, pp. 9–17, 2011.
- P. Balakumar, A. Rohilla, and A. Thangathirupathi, “Gentamicin-induced nephrotoxicity: do we have a promising therapeutic approach to blunt it?” Pharmacological Research, vol. 62, no. 3, pp. 179–186, 2010.
- J. M. Lopez-Novoa, Y. Quiros, L. Vicente, A. I. Morales, and F. J. Lopez-Hernandez, “New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view,” Kidney International, vol. 79, no. 1, pp. 33–45, 2011.
- N. M. Selby, S. Shaw, N. Woodier, R. J. Fluck, and N. V. Kolhe, “Gentamicin-associated acute kidney injury,” QJM, vol. 102, no. 12, pp. 873–880, 2009.
- W. M. Sweileh, “A prospective comparative study of gentamicin- and amikacin-induced nephrotoxicity in patients with normal baseline renal function,” Fundamental & Clinical Pharmacology, vol. 23, no. 4, pp. 515–520, 2009.
- M. Zappitelli, B. S. Moffett, A. Hyder, and S. L. Goldstein, “Acute kidney injury in non-critically ill children treated with aminoglycoside antibiotics in a tertiary healthcare centre: a retrospective cohort study,” Nephrology Dialysis Transplantation, vol. 26, no. 1, pp. 144–150, 2011.
- H. Servais, P. Van Der Smissen, G. Thirion et al., “Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria,” Toxicology and Applied Pharmacology, vol. 206, no. 3, pp. 321–333, 2005.
- A. I. Morales, D. Detaille, M. Prieto et al., “Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway,” Kidney International, vol. 77, no. 10, pp. 861–869, 2010.
- D. B. Zorov, “Amelioration of aminoglycoside nephrotoxicity requires protection of renal mitochondria,” Kidney International, vol. 77, no. 10, pp. 841–843, 2010.
- E. A. Pessoa, M. B. Convento, R. G. Silva, A. S. Oliveira, F. T. Borges, and N. Schor, “Gentamicin-induced preconditioning of proximal tubular LLC-PK1 cells stimulates nitric oxide production but not the synthesis of heat shock protein,” Brazilian Journal of Medical and Biological Research, vol. 42, no. 7, pp. 614–620, 2009.
- H. Servais, Y. Jossin, F. Van Bambeke, P. M. Tulkens, and M.-P. Mingeot-Leclercq, “Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation,” Antimicrobial Agents and Chemotherapy, vol. 50, no. 4, pp. 1213–1221, 2006.
- C. A. Tagliati, D. Romero, E. C. R. Dutra, A. Hernández-García, E. Martínez-López, and A. J. García-Fernández, “A comparison of BGM and LLC-PK1 cells for the evaluation of nephrotoxicity,” Drug and Chemical Toxicology, vol. 35, no. 3, pp. 258–263, 2012.
- M. A. Velasco-Velázquez, P. D. Maldonado, D. Barrera, V. Torres, A. Zentella-Dehesa, and J. Pedraza-Chaverrí, “Aged garlic extract induces proliferation and ameliorates gentamicin-induced toxicity in LLC-PK1 cells,” Phytotherapy Research, vol. 20, no. 1, pp. 76–78, 2006.
- S. Quesney, J. Marvel, A. Marc, C. Gerdil, and B. Meignier, “Characterization of Vero cell growth and death in bioreactor with serum-containing and serum-free media,” Cytotechnology, vol. 35, no. 2, pp. 115–125, 2001.
- N. Adhikari, N. Sinha, and D. K. Saxena, “Effect of lead on Sertoli-germ cell coculture of rat,” Toxicology Letters, vol. 116, no. 1-2, pp. 45–49, 2000.
- S. T. Smiley, M. Reers, C. Mottola-Hartshorn et al., “Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 88, no. 9, pp. 3671–3675, 1991.
- P. D. Maldonado, D. Barrera, I. Rivero et al., “Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage,” Free Radical Biology and Medicine, vol. 35, no. 3, pp. 317–324, 2003.
- J. Pedraza-Chaverrí, D. Barrera, P. D. Maldonado et al., “S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo,” BMC Clinical Pharmacology, vol. 4, article 5, 2004.
- J. Pedraza-Chaverrí, P. D. Maldonado, O. N. Medina-Campos et al., “Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes,” Free Radical Biology and Medicine, vol. 29, no. 7, pp. 602–611, 2000.
- P. D. Maldonado, D. Barrera, O. N. Medina-Campos, R. Hernández-Pando, M. E. Ibarra-Rubio, and J. Pedraza-Chaverrí, “Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats,” Life Sciences, vol. 73, no. 20, pp. 2543–2556, 2003.
- K. Jung, F. Priem, W. Henke, S. Klotzek, and S. Becker, “Evaluation of methods for determining N-acetyl-beta-D-glucosaminidase in urine of rats without purification of urine samples,” Journal of Experimental Animal Science, vol. 34, no. 4, pp. 147–152, 1991.
- C. E. Guerrero-Beltrán, M. Calderón-Oliver, E. Tapia et al., “Sulforaphane protects against cisplatin-induced nephrotoxicity,” Toxicology Letters, vol. 192, no. 3, pp. 278–285, 2010.
- V. N. Sumantran, “Cellular chemosensitivity assays: an overview,” Cancer Cell Culture, vol. 731, pp. 219–236, 2011.
- B. Westermann, “Mitochondrial fusion and fission in cell life and death,” Nature Reviews Molecular Cell Biology, vol. 11, no. 12, pp. 872–884, 2010.
- T. A. Shapiro, J. W. Fahey, K. L. Wade, K. K. Stephenson, and P. Talalay, “Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables,” Cancer Epidemiology, Biomarkers & Prevention, vol. 7, no. 12, pp. 1091–1100, 1998.
- M. J. Cwik, H. Wu, M. Muzzio, D. L. McCormick, and I. Kapetanovic, “Direct quantitation of glucoraphanin in dog and rat plasma by LC-MS/MS,” Journal of Pharmaceutical and Biomedical Analysis, vol. 52, no. 4, pp. 544–549, 2010.
- A. F. Abdull Razis, M. Bagatta, G. R. De Nicola, R. Iori, and C. Ioannides, “Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin,” Lung Cancer, vol. 71, no. 3, pp. 298–305, 2011.
- M.-J. Chen, W.-Y. Tang, C.-W. Hsu et al., “Apoptosis induction in primary human colorectal cancer cell lines and retarded tumor growth in SCID mice by sulforaphane,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 415231, 13 pages, 2012.
- A. Pledgie-Tracy, M. D. Sobolewski, and N. E. Davidson, “Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines,” Molecular Cancer Therapeutics, vol. 6, no. 3, pp. 1013–1021, 2007.
- C. Szabó, “Multiple pathways of peroxynitrite cytotoxicity,” Toxicology Letters, vol. 140-141, pp. 105–112, 2003.
- R. Manikandan, M. Beulaja, R. Thiagarajan, A. Priyadarsini, R. Saravanan, and M. Arumugam, “Ameliorative effects of curcumin against renal injuries mediated by inducible nitric oxide synthase and nuclear factor kappa B during gentamicin-induced toxicity in Wistar rats,” European Journal of Pharmacology, vol. 670, no. 2-3, pp. 578–585, 2011.
- V. G. Antico Arciuch, M. E. Elguero, J. J. Poderoso, and M. C. Carreras, “Mitochondrial regulation of cell cycle and proliferation,” Antioxidants & Redox Signaling, vol. 16, no. 10, pp. 1150–1180, 2012.
- L. B. Pena, C. E. Azpilicueta, and S. M. Gallego, “Sunflower cotyledons cope with copper stress by inducing catalase subunits less sensitive to oxidation,” Journal of Trace Elements in Medicine and Biology, vol. 25, no. 3, pp. 125–129, 2011.
- Y. Miyamoto, Y. H. Koh, Y. S. Park et al., “Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses,” Biological Chemistry, vol. 384, no. 4, pp. 567–574, 2003.
- M. Kinter and R. J. Roberts, “Glutathione consumption and glutathione peroxidase inactivation in fibroblast cell lines by 4-hydroxy-2-nonenal,” Free Radical Biology and Medicine, vol. 21, no. 4, pp. 457–462, 1996.