Electroacupuncture Ameliorates Learning and Memory via Activation of the CREB Signaling Pathway in the Hippocampus to Attenuate Apoptosis after Cerebral Hypoperfusion
Figure 5
Western blotting showing immunoreactivity of apoptosis-related proteins in the hippocampal CA1 area. The Bcl-2 and Bax protein values were calculated as a ratio of Bcl-2 and Bax protein to GAPDH. EA increased the expression of Bcl-2 and decreased the expression of Bax ((a) and (c)). However, the antiapoptotic action of EA was markedly inhibited by ICV injection of H89 ((b) and (d)). The data are expressed as the mean ± SEM. ANOVA statistical analyses were performed to compare the means among the control, model, and EA groups; △ compared with the control group; ▲ compared with the model group. A -test was used to compare the means between the EA + NS and EA + H89 groups; * compared with the EA + NS group.
