Populus balsamifera Extract and Its Active Component Salicortin Reduce Obesity and Attenuate Insulin Resistance in a Diet-Induced Obese Mouse Model
Figure 1
Cumulative changes in body weight (CCBW) in C57BL/6 mice treated with either standard diet (Chow), HFD (DIO), and (a) HFD in combination with P. balsamifera at 125 or 250 mg/kg, or (b) HFD in combination with salicortin. Area under the curve (AUC) of CCBW for (c) total 8-week treatment period, (d) first 4 weeks of treatment (F1), and (e) second 4 weeks of treatment (F2). As mentioned, C57BL/6 mice were administered either standard diet (Chow), HFD (DIO), and for the last 8 of the 16 weeks a HFD in combination with P. balsamifera at 125 or 250 mg/kg, or with Salicortin 12.5 mg/kg. All values are mean ± SEM. Fraction 1 (F1) consists in the AUC between week 0 and 4, and fraction 2 (F2) corresponds to the AUC between week 4 and 8 of administration of the plant extract. The number of animals for the crude plant extract protocol was CHOW (), DIO (), P. balsamifera 125 (), and P. balsamifera 250 (); and for the salicortin protocol: CHOW (), DIO (), salicortin (). †denotes DIO significantly different as compared to Chow (unpaired Student’s t test; ). *denotes significantly different as compared to respective DIO (one way ANOVA; ). denotes significantly different as compared to respective DIO (unpaired Student’s t test; ).
