Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL/6J Mice Fed on a High-Fat Diet

Table 6

Effects of GE on the expression of genes in adipose tissue.

Genes investigated	ND240	HFD60	HFD120	HFD240	HFDMET
Lipolysis
ATGL	1.34±0.34	1.78 ± 0.67^a	6.05 ± 0.42^c	5.69 ± 0.34^c	3.84 ± 0.98^b
HSL	1.98 ± 0.07	2.99 ± 0.17^a	6.73 ± 0.42^c	6.54 ± 0.32^c	4.63 ± 1.16^b
Differentiation
LPL	−1.05 ± 0.09	−1.93 ± 0.18^a	−1.12 ± 0.42^b	−1.17 ± 0.47^b	−2.22 ± 0.99^a
PPAR-𝛾	−1.69 ± 0.19	−2.08 ± 0.69^a	−1.69 ± 0.48^ab	−1.02 ± 0.36^c	−1.07 ± 0.16^c
SREBP-1c	−1.27 ± 0.65	−1.01 ± 0.16^c	−3.10 ± 0.44^a	−2.25 ± 0.30^ab	−2.30 ± 1.13^ab

Results are expressed as fold variation over the appropriate control groups; ND240 indicates fold increase over ND (normal diet control group), and HFD60, HFD120, HFD240, and HFDMET indicate fold increase over HFD (high-fat diet control group). Fold variations less than one were expressed as negative numbers (e.g., a fold variation of 0.50 is expressed as −2.00). Values expressed are means ± S.D of triplicate measurements. Statistical significance was calculated based on the mean ΔCT values by DMRT for only mice fed with high-fat diet with or without GE. For same gene with various treatment groups, superscripts in the different bar with different alphabets (a–c) were significantly different (𝑃<0.05). Superscripts with same alphabets were not significantly different between the treated groups (𝑃>0.05).