- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 190281, 8 pages
Suppressions of Migration and Invasion by Cantharidin in TSGH-8301 Human Bladder Carcinoma Cells through the Inhibitions of Matrix Metalloproteinase-2/-9 Signaling
1Department of Physiology, China Medical University, Taichung 404, Taiwan
2Department of Chinese Medicine, E-DA Hospital/I-Shou University, Kaohsiung 824, Taiwan
3Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan
4Department of Pharmacology, China Medical University, Taichung 404, Taiwan
5Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, St. Martin De Porres Hospital, Chiayi 600, Taiwan
6School of Chinese Medicine, China Medical University, Taichung 404, Taiwan
7Special Class of Healthcare, Industry Management, Central Taiwan University of Science and Technology, Taichung 406, Taiwan
8Department of Urology, Jen-Ai Hospital, Taichung 412, Taiwan
9School of Pharmacy, China Medical University, Taichung 404, Taiwan
10Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan
11Department of Microbiology, China Medical University, Taichung 404, Taiwan
12Department of Biotechnology, Asia University, Taichung 413, Taiwan
Received 11 October 2012; Revised 10 December 2012; Accepted 11 December 2012
Academic Editor: Wei Jia
Copyright © 2013 Yi-Ping Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. A. Hussain and N. D. James, “The systemic treatment of advanced and metastatic bladder cancer,” Lancet Oncology, vol. 4, no. 8, pp. 489–497, 2003.
- B. Y. Hernandez, M. D. Green, K. D. Cassel, A. M. Pobutsky, V. Vu, and L. R. Wilkens, “Preview of Hawaii cancer facts and figures 2010,” Hawaii Medical Journal, vol. 69, no. 9, pp. 223–224, 2010.
- E. M. Messing, T. B. Young, V. B. Hunt et al., “Comparison of bladder cancer outcome in men undergoing hematuria home screening versus those with standard clinical presentations,” Urology, vol. 45, no. 3, pp. 387–397, 1995.
- W. F. Whitmore Jr., “Management of invasive bladder neoplasms,” Seminars in Urology, vol. 1, no. 1, pp. 34–41, 1983.
- X. Zhang, X. Shi, J. Li, et al., “A novel therapeutic vaccine of mouse GM-CSF surface modified MB49 cells against metastatic bladder cancer,” Journal of Urology, vol. 187, no. 3, pp. 1071–1079, 2012.
- D. Raghavan, W. U. Shipley, M. B. Garnick, P. J. Russell, and J. P. Richie, “Biology and management of bladder cancer,” New England Journal of Medicine, vol. 322, no. 16, pp. 1129–1138, 1990.
- J. P. Stein, G. Lieskovsky, R. Cote et al., “Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients,” Journal of Clinical Oncology, vol. 19, no. 3, pp. 666–675, 2001.
- P. L. Liu, J. R. Tsai, A. L. Charles et al., “Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1-mediated nuclear factor-B pathway and subsequently downregulating expression of matrix metalloproteinases,” Molecular Nutrition and Food Research, vol. 54, supplement 2, pp. S196–S204, 2010.
- G. Christofori, “New signals from the invasive front,” Nature, vol. 441, no. 7092, pp. 444–450, 2006.
- A. R. Folgueras, A. M. Pendas, L. M. Sanchez, and C. Lopez-Otin, “Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies,” The International Journal of Developmental Biology, vol. 48, no. 5-6, pp. 411–424, 2004.
- K. Kessenbrock, V. Plaks, and Z. Werb, “Matrix metalloproteinases: regulators of the tumor microenvironment,” Cell, vol. 141, no. 1, pp. 52–67, 2010.
- L. M. Coussens, B. Fingleton, and L. M. Matrisian, “Matrix metalloproteinase inhibitors and cancer: trials and tribulations,” Science, vol. 295, no. 5564, pp. 2387–2392, 2002.
- W. Li, L. Xie, Z. Chen et al., “Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis,” Cancer Science, vol. 101, no. 5, pp. 1226–1233, 2010.
- A. McCluskey, S. P. Ackland, M. C. Bowyer et al., “Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines,” Bioorganic Chemistry, vol. 31, no. 1, pp. 68–79, 2003.
- R. E. Honkanen, “Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A,” FEBS Letters, vol. 330, no. 3, pp. 283–286, 1993.
- P. R. Clarke, I. Hoffmann, G. Draetta, and E. Karsenti, “Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts,” Molecular Biology of the Cell, vol. 4, no. 4, pp. 397–411, 1993.
- Y. Ishida, Y. Furukawa, J. A. Decaprio, M. Saito, and J. D. Griffin, “Treatment of myeloid leukemia cells with the phosphatase inhibitor okadaic acid induces cell cycle arrest at either G1/S or G2/M depending on dose,” Journal of Cellular Physiology, vol. 150, no. 3, pp. 484–492, 1992.
- Y. N. Chen, J. C. Chen, S. C. Yin et al., “Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells,” International Journal of Cancer, vol. 100, no. 2, pp. 158–165, 2002.
- H. S. Kang, B. S. Lee, Y. Yang et al., “Roles of protein phosphatase 1 and 2A in an IL-6-mediated autocrine growth loop of human myeloma cells,” Cellular Immunology, vol. 168, no. 2, pp. 174–183, 1996.
- S. H. Kok, S. J. Cheng, C. Y. Hong et al., “Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio,” Cancer Letters, vol. 217, no. 1, pp. 43–52, 2005.
- D. C. Dorn, C. A. Kou, K. J. Png, and M. A. S. Moore, “The effect of cantharidins on leukemic stem cells,” International Journal of Cancer, vol. 124, no. 9, pp. 2186–2199, 2009.
- S. Yi, J. Wass, P. Vincent, and H. Iland, “Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro,” Leukemia Research, vol. 15, no. 10, pp. 883–886, 1991.
- R. M. Ray, S. Bhattacharya, and L. R. Johnson, “Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells,” Journal of Biological Chemistry, vol. 280, no. 35, pp. 31091–31100, 2005.
- J. H. Kuo, Y. L. Chu, J. S. Yang et al., “Cantharidin induces apoptosis in human bladder cancer TSGH 8301 cells through mitochondria-dependent signal pathways,” International Journal of Oncology, vol. 37, no. 5, pp. 1243–1250, 2010.
- W. W. Huang, S. W. Ko, H. Y. Tsai et al., “Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways,” International Journal of Oncology, vol. 38, no. 4, pp. 1067–1073, 2011.
- N. G. Chen, C. C. Lu, Y. H. Lin et al., “Proteomic approaches to study epigallocatechin gallate-provoked apoptosis of TSGH-8301 human urinary bladder carcinoma cells: roles of AKT and heat shock protein 27-modulated intrinsic apoptotic pathways,” Oncology Reports, vol. 26, no. 4, pp. 939–947, 2011.
- C. C. Lu, J. S. Yang, J. H. Chiang, et al., “Novel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits leukemic mice,” PLoS ONE, vol. 7, no. 5, article e36831, 2012.
- K. C. Liu, A. C. Huang, P. P. Wu et al., “Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways,” Oncology Reports, vol. 26, no. 1, pp. 177–184, 2011.
- C. Y. Ma, W. T. Ji, F. S. Chueh, et al., “Butein inhibits the migration and invasion of SK-HEP-1 human hepatocarcinoma cells through suppressing the ERK, JNK, p38, and uPA signaling multiple pathways,” Journal of Agricultural and Food Chemistry, vol. 59, no. 16, pp. 9032–9038, 2011.
- C. L. Liao, K. C. Lai, A. C. Huang, et al., “Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways,” Food and Chemical Toxicology, vol. 50, no. 5, pp. 1734–1740, 2012.
- Y. Y. Chen, S. Y. Chiang, J. G. Lin et al., “Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9,” International Journal of Oncology, vol. 36, no. 5, pp. 1113–1120, 2010.
- Y. T. Ho, J. S. Yang, T. C. Li et al., “Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-B, u-PA and MMP-2 and -9,” Cancer Letters, vol. 279, no. 2, pp. 155–162, 2009.
- J. H. Chiang, J. S. Yang, C. Y. Ma et al., “Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways,” Chemical Research in Toxicology, vol. 24, no. 1, pp. 20–29, 2011.
- C. C. Lu, J. S. Yang, A. C. Huang et al., “Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells,” Molecular Nutrition and Food Research, vol. 54, no. 7, pp. 967–976, 2010.
- C. C. Lu, J. S. Yang, J. H. Chiang, et al., “Inhibition of invasion and migration by newly synthesized quinazolinone MJ-29 in human oral cancer CAL 27 cells through suppression of MMP-2/9 expression and combined down-regulation of MAPK and AKT signaling,” Anticancer Research, vol. 32, no. 7, pp. 2895–2903, 2012.
- K. C. Lai, A. N. C. Huang, S. C. Hsu et al., “Benzyl Lsothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway,” Journal of Agricultural and Food Chemistry, vol. 58, no. 5, pp. 2935–2942, 2010.
- S. F. Yang, M. K. Chen, Y. S. Hsieh et al., “Antimetastatic effects of Terminalia catappa L. on oral cancer via a down-regulation of metastasis-associated proteases,” Food and Chemical Toxicology, vol. 48, no. 4, pp. 1052–1058, 2010.
- C. Gialeli, A. D. Theocharis, and N. K. Karamanos, “Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting,” The FEBS Journal, vol. 278, no. 1, pp. 16–27, 2011.
- P. N. Chen, Y. S. Hsieh, H. L. Chiou, and S. C. Chu, “Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways,” Chemico-Biological Interactions, vol. 156, no. 2-3, pp. 141–150, 2005.
- Y. C. Hsiao, W. H. Kuo, P. N. Chen et al., “Flavanone and -OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway,” Chemico-Biological Interactions, vol. 167, no. 3, pp. 193–206, 2007.
- J. S. Rao, “Molecular mechanisms of glioma invasiveness: the role of proteases,” Nature Reviews Cancer, vol. 3, no. 7, pp. 489–501, 2003.
- J. Westermarck and V. M. Kähäri, “Regulation of matrix metalloproteinase expression in tumor invasion,” The FASEB Journal, vol. 13, no. 8, pp. 781–792, 1999.