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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 191080, 8 pages
Research Article

Evaluation of the Hypoglycemic Properties of Anacardium humile Aqueous Extract

1Unidade de Biotecnologia, Universidade de Ribeirão Preto, UNAERP, Ribeirão Preto, SP, Brazil
2Departamento de Química, Universidade Federal de Lavras, UFLA, Lavras, MG, Brazil
3Universidade Federal de São João Del Rei, UFSJ, Campus Alto Paraopeba, Ouro Branco, MG, Brazil
4Centro de Estudos de Biomoléculas Aplicadas à Saúde, CEBio, Fundação Oswaldo Cruz, FIOCRUZ Rondônia e Departamento de Medicina, Universidade Federal de Rondônia, UNIR, Porto Velho, RO, Brazil
5Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais Renováveis, IBAMA, Porto Velho, RO, Brazil

Received 20 January 2013; Accepted 7 April 2013

Academic Editor: Taofik O. Sunmonu

Copyright © 2013 Márcio A. Urzêda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The antihyperglycemic effects of several plant extracts and herbal formulations which are used as antidiabetic formulations have been described and confirmed to date. The main objective of this work was to evaluate the hypoglycemic activity of the aqueous extract of Anacardium humile. Although the treatment of diabetic animals with A. humile did not alter body weight significantly, a reduction of the other evaluated parameters was observed. Animals treated with A. humile did not show variation of insulin levels, possibly triggered by a mechanism of blood glucose reduction. Levels of ALT (alanine aminotransferase) decreased in treated animals, suggesting a protective effect on liver. Levels of cholesterol were also reduced, indicating the efficacy of the extract in reestablishing the balance of nutrients. Moreover, a kidney protection may have been achieved due to the partial reestablishment of blood glucose homeostasis, while no nephrotoxicity could be detected for A. humile. The obtained results demonstrate the effectiveness of A. humile extracts in the treatment of alloxan-induced diabetic rats. Therefore, A. humile aqueous extract, popularly known and used by diabetic patients, induced an improvement in the biochemical parameters evaluated during and following treatment of diabetic rats. Thus, a better characterization of the medicinal potential of this plant will be able to provide a better understanding of its mechanisms of action in these pathological processes.