Zeaxanthin Induces Apoptosis in Human Uveal Melanoma Cells through Bcl-2 Family Proteins and Intrinsic Apoptosis Pathway

Figure 1

Phase-contrast photomicrograph of uveal melanoma cells and retinal pigment epithelial (RPE) cells treated with various concentrations of zeaxanthin. Human uveal melanoma cells (SP6.5 and C918) or RPE cells were seeded into 24-well plates at density of 8 × 10⁴/well (4×10⁴/cm²) and treated with zeaxanthin at 10, 30, and 100 μM levels for 48 h. Zeaxanthin at all treated levels significantly decreased number of viable cells in melanoma cells, whereas, it did not affect the cell viability of RPE cells.