Korean Red Ginseng Extract Attenuates 3-Nitropropionic Acid-Induced Huntington’s-Like Symptoms

Figure 4

Preadministration of KRGE reduces striatal lesion volume and neuronal cell loss. (a–g) Representative photographs show the distribution of neuronal cell by cresyl violet staining (a–d) and immunohistochemistry for NeuN antibody (e–h). Asterisks indicate striatal lesions. Scale bar = 50 μm. (i) Proportion of mice with striatal lesion was decreased by preadministration of KRGE (50, 100, and 250 mg/kg/day) in dose-dependent pattern. (j) Lesion area was significantly lower in the 3-NP + KRGE-administrated mice (50, 100, and 250 mg/kg/day) than in the 3NP + saline-administrated mice. (k) The number of NeuN(+) cells in the striatum of 3-NP + KRGE-administrated mice was increased than that in the 3-NP + saline-administrated mice. Statistical significance: *𝑃<0.05 versus 3-NP + saline-administrated mice.

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