Evaluation of wether adjunctive treatment with HBOT compared with treatment with hyperbaric air (placebo) would have any therapeutic effect HBOT a treatment period at 2.5 ATA for 85 min daily (session duration 95 min), five days a week for 8 weeks (40 sessions)
Complete healing of the index ulcer was achieved in 25/48 (), 3 major amputations, 4 minor amputations
Complete healing of the index ulcer was achieved in (), 1 major amputation, 4 minor amputations
Standard therapy (ST) + HBOT HBOT 2-3 ATA for 90 min/2 sessions per day, followed by 1 session on the following day; were healed without surgery treatment; (8) required operative debridement, an amputation, or the use of a flap or skin graft; (4) underwent distal amputation; 0 required proximal amputation
ST daily wound care, dressing changes, local debridement, and control infection of patients were healed without surgery treatment; (50) required either operative debridement, an amputation, or the use of a flap or skin graft; (24) underwent distal amputation; (17) required proximal amputation
Comparison therapy plus treatment in a multiplace HBO chamber Two phases: first (antibacterial) phase uses oxygen at 2.5 ATA for 90 minutes daily; second (reparative) phase uses oxygen at 2.2–2.4 ATA for 90 minutes, 5 days a week
Debridement, topical antimicrobial agents, and occlusive dressing. Empirical antibiotic therapy modified following sensitivity results. Diabetic control with insulin. PTCA or CABG, if needed
Comparison therapy plus treatment in a multiplace HBO chamber. Two phases: first (antibacterial) phase uses oxygen at 2.5 ATA for 90 minutes daily; second (reparative) phase uses oxygen at 2.2–2.4 ATA for 90 minutes, 5 days a week. Mean (SD) number of sessions = 38 (8)
Debridement, topical antimicrobial agents, occlusive dressing. Empirical antibiotic therapy modified following sensitivity results. Diabetic control with insulin. PTCA or CABG, if needed
Conventional management and 4 sessions of hyperbaric oxygen therapy HBO chamber with oxygen at 3 ATA for 45 minutes, 4 sittings over 2 weeks
Regular surgical treatment, incision and drainage, debridement, local dressing with boric acid and bleaching powdered solution, or glycerine acriflavine Amputation for gangrene or infection above the knee Cephalosporins, aminoglycosides, and metronidazole with changes made following sensitivity patterns Diabetic control with insulin
Comparison therapy plus treatment in a multiplace HBO chamber. Two phases: first (antibacterial) phase uses oxygen at 2.8 ATA for 90 minutes daily; second (reparative) phase uses oxygen at 2.5 ATA for 90 minutes. Mean (SD) number of sessions = 34