Bioinformatics Analysis for the Antirheumatic Effects of Huang-Lian-Jie-Du-Tang from a Network Perspective

Table 2

The anti-rheumatic effect scores of representative anti-RA western medicines.

Class of drug	Anti-RA drug	Targets	Effect score
Biological response modifiers	Etanercept	FCGR2C, TNFRSF1B, TNF, LTA, FCGR3B, FCGR3A, FCGR2B, FCGR2A, FCGR1A, C1S, C1R, C1QC, C1QB, C1QA	1.644
	Abatacept	CD86, CD80	0.609
	Infliximab	TNF	0.293
	Anakinra	IL1R1	0.159
DMARDs	Chloroquine	TLR9, TNF, GSTA2	0.463
	Sulfasalazine	SLC7A11, PTGS2, PTGS1, PPARG, IKBKB, CHUK, ALOX5, ACAT1	0.454
	Hydroxychloroquine	TLR9, TLR7	0.173
	Leflunomide	PTK2B, DHODH, AHR	0.149
	Auranofin	PRDX5, IKBKB	0.14
	Leflunomide	PTK2B, DHODH, AHR	0.061
	Azathioprine	HPRT1	0.053
	Auranofin	PRDX5, IKBKB	0.05
NSAIAs	Flurbiprofen	PTGS2, PTGS1	0.133
Glucocorticoids	Cortisone acetate	NR3C1	0.063

RA-associated disease genes are marked in bold characters.