Table 2: The anti-rheumatic effect scores of representative anti-RA western medicines.

Class of drugAnti-RA drugTargetsEffect score

Biological response modifiersEtanerceptFCGR2C, TNFRSF1B, TNF, LTA, FCGR3B, FCGR3A, FCGR2B, FCGR2A, FCGR1A, C1S, C1R, C1QC, C1QB, C1QA1.644
AbataceptCD86, CD800.609
InfliximabTNF0.293
AnakinraIL1R10.159

DMARDsChloroquineTLR9, TNF, GSTA20.463
SulfasalazineSLC7A11, PTGS2, PTGS1, PPARG, IKBKB, CHUK, ALOX5, ACAT10.454
HydroxychloroquineTLR9, TLR70.173
LeflunomidePTK2B, DHODH, AHR0.149
AuranofinPRDX5, IKBKB0.14
LeflunomidePTK2B, DHODH, AHR0.061
AzathioprineHPRT10.053
AuranofinPRDX5, IKBKB0.05

NSAIAsFlurbiprofenPTGS2, PTGS10.133

GlucocorticoidsCortisone acetateNR3C10.063

RA-associated disease genes are marked in bold characters.