Table 4: The network topology analysis about the overlapped genes and target proteins of HLJDT. It mainly included degree of distribution, betweenness, and K-core analysis.

GeneDegreeBetweennessK-corenessRA disease geneTargeted by component of HLJDT

IL6840.05920YBerberine; coptisine; wogonin
IFNG750.04720YBerberine
IL1B630.02920YBerberine; coptisine
JUN590.01620YBerberine; wogonin
IL8580.02620YBerberine; wogonin
VEGFA510.02720YBaicalein; berberine
FOS510.02420YBaicalein; berberine
IL4500.01420YBerberine
CCL2410.00620YBerberine; wogonin
CXCL12330.00919YBerberine
NOS29 9YBerberine; coptisine; wogonin
TNF6 6YBerberine; coptisine; wogonin
RELA560.01220NBaicalein; berberine; wogonin
SRC480.02620NBaicalein
IL2RA440.00320NBerberine
MAPK1420.01620NBerberine
NFKBIA420.00820NBerberine
AKT1420.01020NBaicalein; wogonin
MMP9380.013020NBaicalein
EGFR350.00420NBerberine
FN1340.01015NWogonin
BCL2330.00420NBaicalein; berberine; geniposide; wogonin
PTGS2300.00420NBaicalein; berberine; coptisine; wogonin
RAC1260.00219NBerberine
APP240.00616NBerberine
TP53240.00718NBaicalein; berberine; wogonin
KDR220.00315NWogonin
NFATC1200.00318NBaicalein