Cardiovascular Effects of Salvianolic Acid B

Table 12

Inhibiting left ventricular remodeling of salvianolic acid B in vivo and in vitro.

Type	Cells/tissues	Effects	Reference
In vitro research	LX-2	p38 signaling pathway,; cross effect from the Smad to ERK signaling pathway,; synthesis of type I collagen,	Lv and Xu, 2012 [76]
	HL-60	MMP-9 CD,; cardiac fibroblast migration,; collagen synthesis,; secretion of cytokine (ICAM, TNF-α, IL-6, and sVCAM-1),; expression of VEGF.	Jiang et al., 2010 [77]
	PC12	A-beta aggregation,; fibril formation,; cellular toxicity of aged A-beta.	Tang and Zhang, 2011 [78]
Type	Organ/animals	Effects	Reference
In vivo research	Rat heart	Activity of MMP-9,; increase the thickness of the left ventricular wall,; improve the contraction of the heart,; reduce cardiac fibrosis.	Wang et al., 2011 [75]

Note: MMP-9 CD: catalytic domain of MMP-9; LX-2: stellate cell lines; VCAM-1: vascular cell adhesion molecule-1; ICAM-1: intercellular adhesion molecule 1; IL: interleukin; TNF: tumor necrosis factor; MMP-9 CD: catalytic domain of MMP-9; ERK: extracellular-signal-regulated kinase; VEGF: vascular endothelial growth factor receptor.