Cardiovascular Effects of Salvianolic Acid B

Table 5

Inhibiting ischemia and hypoxia of myocardial injury of salvianolic acid B in vitro.

Type	Cells/tissues	Effects	Reference
In vivo research	Guinea pig heart	Anti-voltage-dependent Ca^2+ channels.	Wang et al., 2006 [41]
	Rat heart	Upregulation of leptin,; upregulation of oxidative stress,; endothelin pathways,; expressions of SERCA2a,; expressions of PLB.	He et al., 2008 [44]
	SAH rat	Induce eNOS expression,; improve endothelial dysfunction,; ET-1 production.	Chang et al., 2011 [46]
Type	Organ/animals	Effects	Reference
In vitro research	HUVEs	Promote L-arginine uptake,; expression of catalase (CAT),; phosphorylation of eNOS,; AMPK-PI3K-Akt signaling pathway,; NO.	Pan et al., 2011 [42]
	Neonatal rat cardiomyocytes	TLR4-NFκB-TNFα signaling pathway.	Wang et al., 2011 [43]

Note: SAH: subarachnoid hemorrhage; TNF-α: tumor necrosis factor α; HUVEC: shuman umbilical vein endothelial cells; NF-κB: nuclear factor κB; TLR: toll-like receptor; eNOS: endothelial nitric oxide synthase.