Cardiovascular Effects of Salvianolic Acid B

Table 6

Endothelial cell protection of salvianolic acid B in vivo and in vitro.

Type	Cells/tissues	Effects	Reference
In vitro research	HAECs	Expression of VCAM-1,; expression of ICAM-1,	Chen et al., 2001 [47]
	HUVECs and HAECs	Akt phosphorylation,; O bit N-acetylglucosamine amine of eNOS,; 3-phosphoinositide kinase/Akt signaling pathway,; expression of Nrf-2	Kim et al., 2010 [48]
	HUVECs	Expression of PAI-1 Mrna.	Zhou et al., 2005 [49]
	HUVECs	Expression of GRP78,; ATF6, and the PERK-eIF2a-ATF4 pathway.	Wu et al., 2009 [50]
Type	Organ/animals	Effects	Reference
In vivo research	OLETF; Diabetic rat	Endothelial dependent; vasodilation,; levels of serum nitrite,; serum AGEs concentration,; reduce the oxidative stress.	Kim et al., 2010 [48]

Note: HUVEC: human umbilical vein endothelial cells; HAEC: human aortic endothelial cells; OLETF: Otsuka Long-Evans Tokushima Fatty; PAI-1: plasminogen activator inhibitor type 1; eNOS: endothelial nitric oxide synthase; VCAM-1: vascular cell adhesion molecule-1; ICAM-1: intercellular adhesion molecule 1.