Review Article
Cardiovascular Effects of Salvianolic Acid B
Table 6
Endothelial cell protection of salvianolic acid B in vivo and in vitro.
| Type | Cells/tissues | Effects | Reference |
| In vitro research | HAECs
| Expression of VCAM-1, expression of ICAM-1, |
Chen et al., 2001 [47] | HUVECs and HAECs | Akt phosphorylation, O bit N-acetylglucosamine amine of eNOS, 3-phosphoinositide kinase/Akt signaling pathway, expression of Nrf-2 |
Kim et al., 2010 [48] | HUVECs | Expression of PAI-1 Mrna. |
Zhou et al., 2005 [49] | HUVECs | Expression of GRP78, ATF6, and the PERK-eIF2a-ATF4 pathway. |
Wu et al., 2009 [50] |
| Type | Organ/animals | Effects | Reference |
| In vivo research | OLETF Diabetic rat | Endothelial dependent vasodilation, levels of serum nitrite, serum AGEs concentration, reduce the oxidative stress. |
Kim et al., 2010 [48] |
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Note: HUVEC: human umbilical vein endothelial cells; HAEC: human aortic endothelial cells; OLETF: Otsuka Long-Evans Tokushima Fatty; PAI-1: plasminogen activator inhibitor type 1; eNOS: endothelial nitric oxide synthase; VCAM-1: vascular cell adhesion molecule-1; ICAM-1: intercellular adhesion molecule 1.
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