Cardiovascular Effects of Salvianolic Acid B

Table 8

Acting on ion channel function of salvianolic acid B in vitro.

Type	Cells/tissues	Effects	Reference
In vitro Research	SH-SY5Y	Suppress Na^+-K^+-ATP enzyme,; increase intracellular Ca^2+ levels.	Chen et al., 2010 [56]
	Porcine CASMs	Activate BKCa channels,; L-NNA insensitive,; BKCa current amplitude,; inhibited L-type Ca^2+ current,; delay rectifier 𝐼K,; inward rectifier 𝐼K.	Lam et al., 2006 [55]
	VSMCs	Activation of BKCa channel,; increase NO release.	Zhang et al., 2010 [54]
Type	Organ/animals	Effects	Reference
In vivo research	Rat coronary artery	Inhibition of Ca^2+ influx.	Lam et al., 2006 [58]

Note: VSMC: vascular smooth muscle cells; BK_Ca: iberiotoxin-sensitive Ca²⁺-activated K⁺ current; 𝐼_Ca,L: L-type Ca²⁺ current; 𝐼_Na: Na⁺ current; 𝐼_K: K⁺ current.