Cardiovascular Effects of Salvianolic Acid B

Table 9

Anti-inflammatory effect of salvianolic acid B in vitro.

Type	Cells/tissues	Effects	Reference
In vitro research	HAECs	Activity of NF-κB.	Sun et al., 2011 [61]
	Endothelial cells	JAK-STAT1 signaling pathway,; inhibit phosphorylation of JAK2,; inhibit phosphorylation of STAT1,; inhibit IP-10, MIG, and I-TAC,; reduce adhesion role of monocyte to endothelial cells,; increase expression of PIAS1,; increase expression of SOCS1.	Chen et al., 2006 [66]
	Rat primary microglia	Production of IL-1b and ROS,; production of NO, TNF-a,; inhibit IL-2, IL-4, TNF-α.	Cheng et al., 2012 [64]
	Human peripheral T lymphocyte	Expressions of CD 25 and CD 69,; down-regulate AP-1, NF-Κb,; down-regulate Oct-1DNA-binding activity,; inhibit c-JNK, IκBα degradation,; inhibit nuclear translocation of p65 and p50, IKK activity,; suppress JNK-AP-1, IKK-IκBα-NF-κB and Oct-1 signaling pathways,; phosphorylation of ERK1/2.	Chen et al., 2011 [65]
	HASMCs	Phosphorylation of JNK,; pathway of ERK1/2, c-JNK, and p38 MAPK,; prostaglandin E2 production,; NADPH oxidase activity.	Chen et al., 2006 [66]
	HAECs	NF-κB activation,; VCAM-1, ICAM-1, and E-selectin.	Xie et al., 2010 [67]
Type	Organ/animals	Effects	Reference
In vivo research	Mice brain	Expression of TNF-α,; expression of IL-1,; expression of IL-10 and TGF-β1.	Chen et al., 2006 [66]

Note: PAI-1: plasminogen activator inhibitor type 1; NF-κB: nuclear factor κB; HAEC: human aortic endothelial cells; p38 MAPK: p38 mitogen-activated protein kinase.