Pummelo Protects Doxorubicin-Induced Cardiac Cell Death by Reducing Oxidative Stress, Modifying Glutathione Transferase Expression, and Preventing Cellular Senescence

Figure 2

Effect of pummelo on intracellular ROS levels. Cardiac H9c2 cells were treated with DOX (0.1 μM) with or without coincubation with CM at concentrations 10, 100, or 1000 μg/mL for 48 h. Fluorescence intensity of DCF was measured and corresponding to intracellular ROS generation. Data are present as % vehicle treated cells (CTRL). ^∗𝑃<0.05 versus CTRL; ^◆𝑃<0.05 versus DOX.