Pummelo Protects Doxorubicin-Induced Cardiac Cell Death by Reducing Oxidative Stress, Modifying Glutathione Transferase Expression, and Preventing Cellular Senescence

<table>Influence of CM on GST activity and expression in H9c2 cells. Cells were treated with DOX (0.1 <i>μ</i>M) and/or pummelo (CM) at concentrations indicated in the Figure. (a) GST activity measurements were performed using total cell lysate as described in Materials and Methods. (b) Western blot analysis of GSTP expression in H9c2 treated with vehicle (CTRL), CM, DOX, or CM and DOX (CM + DOX) for 48 h. <svg height="13.95" id="M14" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus DOX.</table>

Evidence-Based Complementary and Alternative Medicine

fig4

Figure 4

Figure 4: Pummelo Protects Doxorubicin-Induced Cardiac Cell Death by Reducing Oxidative Stress, Modifying Glutathione Transferase Expression, and Preventing Cellular Senescence 

Figure 4 | Pummelo Protects Doxorubicin-Induced Cardiac Cell Death by Reducing Oxidative Stress, Modifying Glutathione Transferase Expression, and Preventing Cellular Senescence 