About this Journal Submit a Manuscript Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 254835, 9 pages
http://dx.doi.org/10.1155/2013/254835
Research Article

Pummelo Protects Doxorubicin-Induced Cardiac Cell Death by Reducing Oxidative Stress, Modifying Glutathione Transferase Expression, and Preventing Cellular Senescence

1Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand
2Department of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand
3Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand

Received 15 November 2012; Accepted 25 December 2012

Academic Editor: Weena Jiratchariyakul

Copyright © 2013 L. Chularojmontri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Takemura and H. Fujiwara, “Doxorubicin-induced cardiomyopathy. From the cardiotoxic mechanisms to management,” Progress in Cardiovascular Diseases, vol. 49, no. 5, pp. 330–352, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Bernhard and G. Laufer, “The aging cardiomyocyte: a mini-review,” Gerontology, vol. 54, no. 1, pp. 24–31, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Maejima, S. Adachi, H. Ito, K. Hirao, and M. Isobe, “Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage,” Aging Cell, vol. 7, no. 2, pp. 125–136, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Li, H. Liu, S. Ramachandran et al., “Grape seed proanthocyanidins ameliorate doxorubicin-induced cardiotoxicity,” American Journal of Chinese Medicine, vol. 38, no. 3, pp. 569–584, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. R. H. Mohamad, A. M. El-Bastawesy, Z. K. Zekry et al., “The role of Curcuma longa against doxorubicin (Adriamycin)-induced toxicity in rats,” Journal of Medicinal Food, vol. 12, no. 2, pp. 394–402, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. O. Benavente-García and J. Castillo, “Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity,” Journal of Agricultural and Food Chemistry, vol. 56, no. 15, pp. 6185–6205, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Pichaiyongvongdee and R. Haruenkit, “Investigation of limonoids, flavanones, total polyphenol content and antioxidant activity in seven thai pummelo cultivars,” Kasetsart Journal, vol. 43, no. 3, pp. 458–466, 2009. View at Scopus
  8. T. L'Ecuyer, Z. Allebban, R. Thomas, and R. Vander Heide, “Glutathione S-transferase overexpression protects against anthracycline-induced H9C2 cell death,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 286, no. 6, pp. H2057–H2064, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Chularojmontri, Y. Ihara, E. Muroi, S. Goto, T. Kondo, and S. K. Wattanapitayakul, “Cytoprotective role of Phyllanthus urinaria L. and glutathione-S transferase Pi in doxorubicin-induced toxicity in H9c2 cells,” Journal of the Medical Association of Thailand, vol. 92, supplement 3, pp. S43–S51, 2009. View at Scopus
  10. L. Ding, X. Luo, F. Tang, J. Yuan, Q. Liu, and S. Yao, “Simultaneous determination of flavonoid and alkaloid compounds in Citrus herbs by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry,” Journal of Chromatography B, vol. 857, no. 2, pp. 202–209, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Scartezzini, F. Antognoni, M. A. Raggi, F. Poli, and C. Sabbioni, “Vitamin C content and antioxidant activity of the fruit and of the Ayurvedic preparation of Emblica officinalis Gaertn,” Journal of Ethnopharmacology, vol. 104, no. 1-2, pp. 113–118, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Swatsitang, G. Tucker, K. Robards, and D. Jardine, “Isolation and identification of phenolic compounds in Citrus sinensis,” Analytica Chimica Acta, vol. 417, no. 2, pp. 231–240, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. S. K. Wattanapitayakul, L. Chularojmontri, A. Herunsalee, S. Charuchongkolwongse, S. Niumsakul, and J. A. Bauer, “Screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity,” Basic and Clinical Pharmacology and Toxicology, vol. 96, no. 1, pp. 80–87, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. O. W. Griffith, “Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine,” Analytical Biochemistry, vol. 106, no. 1, pp. 207–212, 1980. View at Scopus
  15. G. P. Dimri, X. Lee, G. Basile et al., “A biomarker that identifies senescent human cells in culture and in aging skin in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 20, pp. 9363–9367, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. S. V. Kalivendi, S. Kotamraju, H. Zhao, J. Joseph, and B. Kalyanaraman, “Doxorubicin-induced apoptosis is associated with increased transcription of endothelial nitric-oxide synthase: effect of antiapoptotic antioxidants and calcium,” Journal of Biological Chemistry, vol. 276, no. 50, pp. 47266–47276, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Wang, E. A. Konorev, S. Kotamraju, J. Joseph, S. Kalivendi, and B. Kalyanaraman, “Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms: intermediacy of H2O2- and p53-dependent pathways,” Journal of Biological Chemistry, vol. 279, no. 24, pp. 25535–25543, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. J. M. Berthiaume and K. B. Wallace, “Adriamycin-induced oxidative mitochondrial cardiotoxicity,” Cell Biology and Toxicology, vol. 23, no. 1, pp. 15–25, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Shi, C. C. Huang, R. S. Aronstam, N. Ercal, A. Martin, and Y. W. Huang, “N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes,” BMC Pharmacology, vol. 9, article 7, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Rolland, M. Raharijaona, A. Barbarat, R. Houlgatte, and C. Thieblemont, “Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin,” Anticancer Research, vol. 30, no. 10, pp. 3951–3957, 2010. View at Scopus
  21. R. C. Strange, M. A. Spiteri, S. Ramachandran, and A. A. Fryer, “Glutathione-S-transferase family of enzymes,” Mutation Research, vol. 482, no. 1-2, pp. 21–26, 2001. View at Scopus
  22. T. R. Knight, S. Choudhuri, and C. D. Klaassen, “Constitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice,” Toxicological Sciences, vol. 100, no. 2, pp. 513–524, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Joshi, S. Hardas, R. Sultana, D. K. S. Clair, M. Vore, and D. A. Butterfield, “Glutathione elevation by γ-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: implication for chemobrain,” Journal of Neuroscience Research, vol. 85, no. 3, pp. 497–503, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. S. T. Yu, T. M. Chen, J. W. Chern, S. Y. Tseng, and Y. H. Chen, “Downregulation of GSTpi expression by tryptanthrin contributing to sensitization of doxorubicin-resistant MCF-7 cells through c-jun NH2-terminal kinase-mediated apoptosis,” Anti-Cancer Drugs, vol. 20, no. 5, pp. 382–388, 2009. View at Scopus
  25. D. L. Ramos, J. F. Gaspar, M. Pingarilho et al., “Genotoxic effects of doxorubicin in cultured human lymphocytes with different glutathione S-transferase genotypes,” Mutation Research, vol. 724, no. 1-2, pp. 28–34, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Seitz, M. Bonin, J. Fuchs et al., “Inhibition of glutathione-S-transferase as a treatment strategy for multidrug resistance in childhood rhabdomyosarcoma,” International Journal of Oncology, vol. 36, no. 2, pp. 491–500, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. Y.-W. Zhang, J. Shi, Y.-J. Li, and L. Wei, “Cardiomyocyte death in doxorubicin-induced cardiotoxicity,” Archivum Immunologiae et Therapiae Experimentalis, vol. 57, no. 6, pp. 435–445, 2009. View at Publisher · View at Google Scholar
  28. P. Spallarossa, P. Altieri, C. Aloi et al., “Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 297, no. 6, pp. H2169–H2181, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. J. M. Bae, E. J. Lee, and G. Guyatt, “Citrus fruit intake and stomach cancer risk: a quantitative systematic review,” Gastric Cancer, vol. 11, no. 1, pp. 23–32, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. N. P. Aptekmann and T. B. Cesar, “Orange juice improved lipid profile and blood lactate of overweight middle-aged women subjected to aerobic training,” Maturitas, vol. 67, no. 4, pp. 343–347, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. S. P. Johnsen, K. Overvad, C. Stripp, A. Tjønneland, S. E. Husted, and H. T. Sørensen, “Intake of fruit and vegetables and the risk of ischemic stroke in a cohort of Danish men and women,” American Journal of Clinical Nutrition, vol. 78, no. 1, pp. 57–64, 2003. View at Scopus
  32. W. Stuetz, T. Prapamontol, S. Hongsibsong, and H. K. Biesalski, “Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines (citrus reticulata blanco cv. sainampueng) from Northern Thailand,” Journal of Agricultural and Food Chemistry, vol. 58, no. 10, pp. 6069–6074, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Barberis, G. Bazzu, G. Calia et al., “New ultralow-cost telemetric system for a rapid electrochemical detection of vitamin C in fresh orange juice,” Analytical Chemistry, vol. 82, no. 12, pp. 5134–5140, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. A. G. Duzzioni, A. G. Franco, and C. M. de Sylos, “Radical scavenging activity of orange and tangerine varieties cultivated in Brazil,” International Journal of Food Sciences and Nutrition, vol. 60, no. 6, pp. 107–115, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. S. M. Snyder, J. D. Reber, B. L. Freeman, K. Orgad, D. L. Eggett, and T. L. Parker, “Controlling for sugar and ascorbic acid, a mixture of flavonoids matching navel oranges significantly increases human postprandial serum antioxidant capacity,” Nutrition Research, vol. 31, no. 7, pp. 519–526, 2011. View at Publisher · View at Google Scholar