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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 254835, 9 pages
Pummelo Protects Doxorubicin-Induced Cardiac Cell Death by Reducing Oxidative Stress, Modifying Glutathione Transferase Expression, and Preventing Cellular Senescence
1Department of Preclinical Sciences, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand
2Department of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand
3Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand
Received 15 November 2012; Accepted 25 December 2012
Academic Editor: Weena Jiratchariyakul
Copyright © 2013 L. Chularojmontri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- G. Takemura and H. Fujiwara, “Doxorubicin-induced cardiomyopathy. From the cardiotoxic mechanisms to management,” Progress in Cardiovascular Diseases, vol. 49, no. 5, pp. 330–352, 2007.
- D. Bernhard and G. Laufer, “The aging cardiomyocyte: a mini-review,” Gerontology, vol. 54, no. 1, pp. 24–31, 2008.
- Y. Maejima, S. Adachi, H. Ito, K. Hirao, and M. Isobe, “Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage,” Aging Cell, vol. 7, no. 2, pp. 125–136, 2008.
- J. Li, H. Liu, S. Ramachandran et al., “Grape seed proanthocyanidins ameliorate doxorubicin-induced cardiotoxicity,” American Journal of Chinese Medicine, vol. 38, no. 3, pp. 569–584, 2010.
- R. H. Mohamad, A. M. El-Bastawesy, Z. K. Zekry et al., “The role of Curcuma longa against doxorubicin (Adriamycin)-induced toxicity in rats,” Journal of Medicinal Food, vol. 12, no. 2, pp. 394–402, 2009.
- O. Benavente-García and J. Castillo, “Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity,” Journal of Agricultural and Food Chemistry, vol. 56, no. 15, pp. 6185–6205, 2008.
- S. Pichaiyongvongdee and R. Haruenkit, “Investigation of limonoids, flavanones, total polyphenol content and antioxidant activity in seven thai pummelo cultivars,” Kasetsart Journal, vol. 43, no. 3, pp. 458–466, 2009.
- T. L'Ecuyer, Z. Allebban, R. Thomas, and R. Vander Heide, “Glutathione S-transferase overexpression protects against anthracycline-induced H9C2 cell death,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 286, no. 6, pp. H2057–H2064, 2004.
- L. Chularojmontri, Y. Ihara, E. Muroi, S. Goto, T. Kondo, and S. K. Wattanapitayakul, “Cytoprotective role of Phyllanthus urinaria L. and glutathione-S transferase Pi in doxorubicin-induced toxicity in H9c2 cells,” Journal of the Medical Association of Thailand, vol. 92, supplement 3, pp. S43–S51, 2009.
- L. Ding, X. Luo, F. Tang, J. Yuan, Q. Liu, and S. Yao, “Simultaneous determination of flavonoid and alkaloid compounds in Citrus herbs by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry,” Journal of Chromatography B, vol. 857, no. 2, pp. 202–209, 2007.
- P. Scartezzini, F. Antognoni, M. A. Raggi, F. Poli, and C. Sabbioni, “Vitamin C content and antioxidant activity of the fruit and of the Ayurvedic preparation of Emblica officinalis Gaertn,” Journal of Ethnopharmacology, vol. 104, no. 1-2, pp. 113–118, 2006.
- P. Swatsitang, G. Tucker, K. Robards, and D. Jardine, “Isolation and identification of phenolic compounds in Citrus sinensis,” Analytica Chimica Acta, vol. 417, no. 2, pp. 231–240, 2000.
- S. K. Wattanapitayakul, L. Chularojmontri, A. Herunsalee, S. Charuchongkolwongse, S. Niumsakul, and J. A. Bauer, “Screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity,” Basic and Clinical Pharmacology and Toxicology, vol. 96, no. 1, pp. 80–87, 2005.
- O. W. Griffith, “Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine,” Analytical Biochemistry, vol. 106, no. 1, pp. 207–212, 1980.
- G. P. Dimri, X. Lee, G. Basile et al., “A biomarker that identifies senescent human cells in culture and in aging skin in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 20, pp. 9363–9367, 1995.
- S. V. Kalivendi, S. Kotamraju, H. Zhao, J. Joseph, and B. Kalyanaraman, “Doxorubicin-induced apoptosis is associated with increased transcription of endothelial nitric-oxide synthase: effect of antiapoptotic antioxidants and calcium,” Journal of Biological Chemistry, vol. 276, no. 50, pp. 47266–47276, 2001.
- S. Wang, E. A. Konorev, S. Kotamraju, J. Joseph, S. Kalivendi, and B. Kalyanaraman, “Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms: intermediacy of H2O2- and p53-dependent pathways,” Journal of Biological Chemistry, vol. 279, no. 24, pp. 25535–25543, 2004.
- J. M. Berthiaume and K. B. Wallace, “Adriamycin-induced oxidative mitochondrial cardiotoxicity,” Cell Biology and Toxicology, vol. 23, no. 1, pp. 15–25, 2007.
- R. Shi, C. C. Huang, R. S. Aronstam, N. Ercal, A. Martin, and Y. W. Huang, “N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes,” BMC Pharmacology, vol. 9, article 7, 2009.
- D. Rolland, M. Raharijaona, A. Barbarat, R. Houlgatte, and C. Thieblemont, “Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin,” Anticancer Research, vol. 30, no. 10, pp. 3951–3957, 2010.
- R. C. Strange, M. A. Spiteri, S. Ramachandran, and A. A. Fryer, “Glutathione-S-transferase family of enzymes,” Mutation Research, vol. 482, no. 1-2, pp. 21–26, 2001.
- T. R. Knight, S. Choudhuri, and C. D. Klaassen, “Constitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice,” Toxicological Sciences, vol. 100, no. 2, pp. 513–524, 2007.
- G. Joshi, S. Hardas, R. Sultana, D. K. S. Clair, M. Vore, and D. A. Butterfield, “Glutathione elevation by γ-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: implication for chemobrain,” Journal of Neuroscience Research, vol. 85, no. 3, pp. 497–503, 2007.
- S. T. Yu, T. M. Chen, J. W. Chern, S. Y. Tseng, and Y. H. Chen, “Downregulation of GSTpi expression by tryptanthrin contributing to sensitization of doxorubicin-resistant MCF-7 cells through c-jun NH2-terminal kinase-mediated apoptosis,” Anti-Cancer Drugs, vol. 20, no. 5, pp. 382–388, 2009.
- D. L. Ramos, J. F. Gaspar, M. Pingarilho et al., “Genotoxic effects of doxorubicin in cultured human lymphocytes with different glutathione S-transferase genotypes,” Mutation Research, vol. 724, no. 1-2, pp. 28–34, 2011.
- G. Seitz, M. Bonin, J. Fuchs et al., “Inhibition of glutathione-S-transferase as a treatment strategy for multidrug resistance in childhood rhabdomyosarcoma,” International Journal of Oncology, vol. 36, no. 2, pp. 491–500, 2010.
- Y.-W. Zhang, J. Shi, Y.-J. Li, and L. Wei, “Cardiomyocyte death in doxorubicin-induced cardiotoxicity,” Archivum Immunologiae et Therapiae Experimentalis, vol. 57, no. 6, pp. 435–445, 2009.
- P. Spallarossa, P. Altieri, C. Aloi et al., “Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 297, no. 6, pp. H2169–H2181, 2009.
- J. M. Bae, E. J. Lee, and G. Guyatt, “Citrus fruit intake and stomach cancer risk: a quantitative systematic review,” Gastric Cancer, vol. 11, no. 1, pp. 23–32, 2008.
- N. P. Aptekmann and T. B. Cesar, “Orange juice improved lipid profile and blood lactate of overweight middle-aged women subjected to aerobic training,” Maturitas, vol. 67, no. 4, pp. 343–347, 2010.
- S. P. Johnsen, K. Overvad, C. Stripp, A. Tjønneland, S. E. Husted, and H. T. Sørensen, “Intake of fruit and vegetables and the risk of ischemic stroke in a cohort of Danish men and women,” American Journal of Clinical Nutrition, vol. 78, no. 1, pp. 57–64, 2003.
- W. Stuetz, T. Prapamontol, S. Hongsibsong, and H. K. Biesalski, “Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines (citrus reticulata blanco cv. sainampueng) from Northern Thailand,” Journal of Agricultural and Food Chemistry, vol. 58, no. 10, pp. 6069–6074, 2010.
- A. Barberis, G. Bazzu, G. Calia et al., “New ultralow-cost telemetric system for a rapid electrochemical detection of vitamin C in fresh orange juice,” Analytical Chemistry, vol. 82, no. 12, pp. 5134–5140, 2010.
- A. G. Duzzioni, A. G. Franco, and C. M. de Sylos, “Radical scavenging activity of orange and tangerine varieties cultivated in Brazil,” International Journal of Food Sciences and Nutrition, vol. 60, no. 6, pp. 107–115, 2009.
- S. M. Snyder, J. D. Reber, B. L. Freeman, K. Orgad, D. L. Eggett, and T. L. Parker, “Controlling for sugar and ascorbic acid, a mixture of flavonoids matching navel oranges significantly increases human postprandial serum antioxidant capacity,” Nutrition Research, vol. 31, no. 7, pp. 519–526, 2011.