In Vitro Morphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes of Curcuma zedoaria

Table 1

Cytotoxic activity (IC₅₀ values (μg/mL)) of crude and fractionated extracts of Curcuma zedoaria against human cancer and noncancer cell lines.

Extracts	IC50 (μg/mL)
	KB	Ca Ski	MCF-7	HCT-116	A549	MRC-5
Methanol	14.4±0.7	14.2±1.5	21.0±1.6	68.4±1.3	28.0±0.9	36.5±2.0
Hexane	29.0±1.1	16.4±0.9	18.9±0.7	41.1±0.9	56.0±0.7	37.5±1.8
Ethyl acetate	29.0±0.5	21.5±1.7	21.3±1.1	21.0±1.0	57.0±1.2	63.4±1.6
Water	>100	>100	>100	>100	>100	>100
*Doxorubicin	0.27±0.01	0.18±0.06	0.05±0.01	0.24±0.04	0.58±0.01	0.40±0.03

∗Doxorubicin was used as the positive reference compound. Tabulated values are mean ± standard deviation (SD) of three replicates.