Advancing Drug Discovery and Development from Active Constituents of Yinchenhao Tang, a Famous Traditional Chinese Medicine Formula
Figure 2
Chemical structure of chlorogenic acid, geniposide, 6,7-dimethylesculetin, capillarisin, and rhein. (b) Comparison of fingerprint profiles of twelve batches of YCHTE samples. Among fifteen representative general peaks, the peaks 2, 3, 6, 7, 8, 9, 10, 11, 12, and 14 originated from the flowers of Artemisia capillaries Thunb, the peaks 2, 4, and 5 originated from the fruits of Gardenia jasminoides Ellis, and the peaks 1, 13, and 15 originated from the roots of Rheum officinale Baill. The peaks 2, 5, 7, 14, and 15 are of chlorogenic acid, geniposide, 6,7-dimethylesculetin, capillarisin, and rhein, respectively. The fingerprint chromatograms of twelve batches of YCHT samples which are consisted of herbal drugs collected from different places of production, is from chromatogram a to chromatogram j. (c) HPLC chromatogram of (a), YCHTE in methanol; (b), the chemical references of five analytes in methanol: (1) chlorogenic acid; (2) geniposide; (3) 6,7-dimethylesculetin; (4) capillarisin; and (5) rhein.
