Research Article

BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells

Figure 5

Proposed mechanism for pterostilbene-mediated anti-CSC effects. Pterostilbene suppresses CSC generation by negatively regulating the expression levels of c-Myc and CD133 and inhibiting EMT by downregulating Twist1, vimentin, and COX-2 expressions. The double arrow implies that EMT is associated with the increasing stemness of cancer stem cells. Blunt arrow represents suppression.
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