Metabolomic Analysis of Complex Chinese Remedies: Examples of Induced Nephrotoxicity in the Mouse from a Series of Remedies Containing Aristolochic Acid
Figure 4
Perturbed metabolic pathways in response to AA substance exposure. (a) Energy metabolism, several amino acids, and creatinine are influenced. The metabolite concentrations are significantly increased for lactate, glucose, taurine, glycine, valine, and creatine for AA5 and AA7.5 on days 8–10 in Experiment 1. (b) Changes for M0.5 and BF0.5 on days 10–13 in Experiment 2. DMG dimethylglycine, TMAO trimethylamine-N-oxide. Symbols in the cell represent relative concentration change of assigned metabolite between groups. They are significant increase (the black arrow up word)/decrease (the black arrow down word), ; nonsignificant increase (the white arrow up word)/decrease (the white arrow down word), fold change > 2; no significant difference ().
