Antiulcer Activity of Indigenous Plant Operculina turpethum Linn.

Table 1

(a) Effect of HAOP and MOP pretreatment on aspirin + pylorus ligation-induced gastric lesions in rats. (b) Effect of HAOP and MOP posttreatment on aspirin + pylorus ligation-induced gastric lesions in rats.

(a)

Pretreatment	Dose (mg/kg)	Ulcer index	Protection (%)
Aspirin + pylorus ligated control	—	4.39 ± 0.04 a*	—
Ranitidine	50 mg/kg/p.o	1.53 ± 0.02 a*b*	65.14
MOP	100 mg/kg/p.o	1.03 ± 0.009 b*c*	76.53
HAOP	100 mg/kg/p.o	0.82 ± 0.007 a*b*c*	81.32

(b)

Posttreatment	Dose (mg/kg)	Ulcer index	Protection (%)
Aspirin + pylorus ligated control	—	4.39 ± 0.04 a*	—
Ranitidine	50 mg/kg/p.o	1.53 ± 0.02 a*b*	65.14
MOP	100 mg/kg/p.o	2.01 ± 0.02 a*b*c*	54.21
HAOP	100 mg/kg/p.o	1.75 ± 0.02 a*b*c*	60.13

The following values are expressed as mean ± SEM of 6 animals.
Comparisons were made between.
a: Group I versus II, III, IV, V, VI, and VII.
b: Group II versus III, IV, V, VI, and VII.
c: Group III versus V and VII.
Symbols represent statistical significance: *𝑃<0.001, ^#𝑃<0.01, ^@𝑃<0.05.