Bioactive Lipidic Extracts from Octopus (Paraoctopus limaculatus): Antimutagenicity and Antiproliferative Studies

Table 1

Antimutagenic potential of extracts from fractions RA, RB, and RC obtained from lipidic extract of octopus (average^a TA100 and TA98 revertants/plate, with S9).

Extract fraction^c	Fraction dilution^c
	1×10^0	1×10^−1	1×10^−2	1×10^−3
TA98
RA (𝑅𝑓 = 0.0–0.29)	170±13	296±24	267±13	333±18
RB (𝑅𝑓 = 0.29–0.69)	117±10	271±18	338±27	350±31
RC (𝑅𝑓 = 0.69–1.0)	215±7	387±23	299±21	453±33
TA100
RA (𝑅𝑓 = 0.0–0.29)	71±16	203±12	567±35	621±53
RB (𝑅𝑓 = 0.29–0.69)	127±3	361±39	534±37	567±24
RC (𝑅𝑓 = 0.69–1.0)	185±15	565±43	523±48	536±30

^aAFB₁ (used as positive control) tested at 100, 500, and 1000 ng/plate induced 195±23, 495±29, and 676±55 and 200±16, 595±43, and 745±24 revertants/plate for TA98 and TA100, respectively. Spontaneous revertants were 55±7 and 113±19 for TA98 and TA100, respectively.
^bValues are means of three replicates ± SEM.
^cExtracts were diluted and spiked with enough toxin to yield 500 ng of pure AFB₁/plate.