The Application of SILAC Mouse in Human Body Fluid Proteomics Analysis Reveals Protein Patterns Associated with IgA Nephropathy

Table 1

The significant proteins associated with nephropathy.

Peptide sequence	Protein name	Fold changes treated : untreated	Relevance with nephropathy	Reference
ACEPGVDYVYK	Complement C3	−3.3	Reported as a potentially novel predictor of progressive IgA nephropathy	[19]
HEVTGWVLVSPLSK	Insulin-like growth factor-binding protein 7	−3.2	The urinary levels of other IGFBPs correlated with the development of renal disease	[20]
VHTECCHGDLLECADDRADLAK	Albumin	−2.3	Most famous indicator for nephropathy	[21, 22]
YICENQDSISSKLK		−2.0
AEFAEVSK		−1.9
AAFTECCQAADKAACLLPK		−1.6
HQPQEFPTYVEPTNDEICEAFRK	Vitamin D-binding protein isoform 3	−2.1	Enhanced excretion in urine during diabetic nephropathy	[23]
DSGRDYVSQFEGSALGK	Apolipoprotein A-I	−2.1	Increased in the plasma of diabetic nephropathy patients	[24]
HYYIGIIETTWDYASDHGEK	Ceruloplasmin	−1.7	Enhanced excretion in urine during diabetic nephropathy	[25, 26]
SSFVAPLEK	Pigment epithelium-derived factor	−1.6	A urinary marker for diabetic nephropathy	[27]
DSAHGFLK	Transferrin	−1.6	Enhanced excretion in urine during diabetic nephropathy	[22, 28]