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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 278405, 13 pages
http://dx.doi.org/10.1155/2013/278405
Research Article
Vitexicarpin Acts as a Novel Angiogenesis Inhibitor and Its Target Network
1MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST, Department of Automation, Tsinghua University, Beijing 100084, China
2Joint Computational Center of Drug Discovery, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China
Received 22 October 2012; Accepted 20 November 2012
Academic Editor: Weidong Zhang
Copyright © 2013 Bo Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- R. K. Jain, “Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy,” Nature Medicine, vol. 7, no. 9, pp. 987–989, 2001. View at Publisher · View at Google Scholar · View at Scopus
- P. Carmeliet, “Angiogenesis in life, disease and medicine,” Nature, vol. 438, no. 7070, pp. 932–936, 2005. View at Publisher · View at Google Scholar · View at Scopus
- S. Wang, Z. Zheng, Y. Weng et al., “Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts,” Life Sciences, vol. 74, no. 20, pp. 2467–2478, 2004. View at Publisher · View at Google Scholar · View at Scopus
- T. P. Fan, J. C. Yeh, K. W. Leung, P. Y. K. Yue, and R. N. S. Wong, “Angiogenesis: from plants to blood vessels,” Trends in Pharmacological Sciences, vol. 27, no. 6, pp. 297–309, 2006. View at Publisher · View at Google Scholar · View at Scopus
- M. Mochizuki, Yung Choon Yoo, K. Matsuzawa et al., “Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside- Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of Red ginseng,” Biological and Pharmaceutical Bulletin, vol. 18, no. 9, pp. 1197–1202, 1995. View at Scopus
- M. W. Chen, L. Yang, L. Ni, and C. Huang, “The effects of 20(R)-Rg3 on lung carcinoma A549 cell line and endogenous VEGF secreted by tumor cells,” Journal of Sichuan University, vol. 37, no. 1, pp. 60–62, 2006. View at Scopus
- K. B. Hu, Z. H. Liu, D. Liu, and L. S. Li, “Inhibition of vascular endothelial growth factor expression and production by triptolide,” Planta Medica, vol. 68, no. 4, pp. 368–369, 2002. View at Publisher · View at Google Scholar · View at Scopus
- B. Wang, L. Ma, X. Tao, and P. E. Lipsky, “Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription,” Arthritis and Rheumatism, vol. 50, no. 9, pp. 2995–3003, 2004. View at Publisher · View at Google Scholar · View at Scopus
- S. Li, A. P. Lu, Y. Y. Wang, and Y. D. Li, “Suppressive effects of a Chinese herbal medicine Qing-Luo-Yin extract on the angiogenesis of collagen-induced arthritis in rats,” American Journal of Chinese Medicine, vol. 31, no. 5, pp. 713–720, 2003. View at Publisher · View at Google Scholar · View at Scopus
- T. W. Kok, P. Y. K. Yue, N. K. Mak, T. P. D. Fan, L. Liu, and R. N. S. Wong, “The anti-angiogenic effect of sinomenine,” Angiogenesis, vol. 8, no. 1, pp. 3–12, 2005. View at Publisher · View at Google Scholar · View at Scopus
- S. Li, B. Zhang, and N. Zhang, “Network target for screening synergistic drug combinations with application to traditional Chinese medicine,” BMC Systems Biology, vol. 5, supplement 1, article S10, 2011. View at Publisher · View at Google Scholar · View at Scopus
- D. X. Hou and T. Kumamoto, “Flavonoids as protein kinase inhibitors for cancer chemoprevention: direct binding and molecular modeling,” Antioxidants and Redox Signaling, vol. 13, no. 5, pp. 691–719, 2010. View at Publisher · View at Google Scholar · View at Scopus
- F. Díaz, D. Chávez, D. Lee et al., “Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo,” Journal of Natural Products, vol. 66, no. 6, pp. 865–867, 2003. View at Scopus
- J. Kobayakawa, F. Sato-Nishimori, M. Moriyasu, and Y. Matsukawa, “G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.),” Cancer Letters, vol. 208, no. 1, pp. 59–64, 2004. View at Publisher · View at Google Scholar · View at Scopus
- K. M. You, K. H. Son, H. W. Chang, S. S. Kang, and H. P. Kim, “Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro,” Planta Medica, vol. 64, no. 6, pp. 546–550, 1998. View at Scopus
- S. M. Lee, Y. J. Lee, Y. C. Kim, J. S. Kim, D. G. Kang, and H. S. Lee, “Vascular Protective Role of Vitexicarpin Isolated from Vitex rotundifolia in Human Umbilical Vein Endothelial Cells,” Inflammation, vol. 35, pp. 584–593, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. Li, B. Zhang, D. Jiang, Y. Wei, and N. Zhang, “Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae,” BMC Bioinformatics, vol. 11, supplement 11, article S6, 2010. View at Publisher · View at Google Scholar · View at Scopus
- I. Paterson and E. A. Anderson, “The renaissance of natural products as drug candidates,” Science, vol. 310, no. 5747, pp. 451–453, 2005. View at Publisher · View at Google Scholar · View at Scopus
- A. L. Hopkins, “Network pharmacology: the next paradigm in drug discovery,” Nature Chemical Biology, vol. 4, no. 11, pp. 682–690, 2008. View at Publisher · View at Google Scholar · View at Scopus
- J. van der Greef and R. N. McBurney, “Rescuing drug discovery: in vivo systems pathology and systems pharmacology,” Nature Reviews Drug Discovery, vol. 4, no. 12, pp. 961–967, 2005. View at Publisher · View at Google Scholar · View at Scopus
- S. I. Berger, A. Ma'ayan, and R. Iyengar, “Systems pharmacology of arrhythmias,” Science Signaling, vol. 3, no. 118, p. ra30, 2010. View at Publisher · View at Google Scholar · View at Scopus
- T. R. Burkard, U. Rix, F. P. Breitwieser, G. Superti-Furga, and J. Colinge, “A computational approach to analyze the mechanism of action of the kinase inhibitor bafetinib,” PLoS Computational Biology, vol. 6, no. 11, Article ID e1001001, 2010. View at Publisher · View at Google Scholar · View at Scopus
- X. Wu, R. Jiang, M. Q. Zhang, and S. Li, “Network-based global inference of human disease genes,” Molecular Systems Biology, vol. 4, pp. 189–199, 2008.
- A. L. Barabási, N. Gulbahce, and J. Loscalzo, “Network medicine: a network-based approach to human disease,” Nature Reviews Genetics, vol. 12, no. 1, pp. 56–68, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. Li, “Framework and practice of network-based studies for Chinese herbal formula,” Journal of Chinese Integrative Medicine, vol. 5, no. 5, pp. 489–493, 2007. View at Publisher · View at Google Scholar · View at Scopus
- S. Li, “Network systems underlying traditional Chinese medicine syndrome and herb formula,” Current Bioinformatics, vol. 4, no. 3, pp. 188–196, 2009. View at Publisher · View at Google Scholar · View at Scopus
- J. Zhao, P. Jiang, and W. Zhang, “Molecular networks for the study of TCM pharmacology,” Briefings in Bioinformatics, vol. 11, no. 4, Article ID bbp063, pp. 417–430, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. Li, “Network target: a starting point for traditional Chinese medicine network pharmacology,” Zhongguo Zhong Yao Za Zhi, vol. 36, pp. 2017–2020, 2011.
- S. Zhao and S. Li, “Network-based relating pharmacological and genomic spaces for drug target identification,” PLoS ONE, vol. 5, no. 7, Article ID e11764, 2010. View at Publisher · View at Google Scholar · View at Scopus
- F. A. Fierro, S. Kalomoiris, C. S. Sondergaard, and J. A. Nolta, “Effects on proliferation and differentiation of multipotent bone marrow stromal cells engineered to express growth factors for combined cell and gene therapy,” Stem Cells, vol. 29, no. 11, pp. 1727–1737, 2011. View at Publisher · View at Google Scholar
- M. Richardson and G. Singh, “Observations on the use of the avian choriallantoic membrane (CAM) model in investigations into angiogenesis,” Current Drug Targets—Cardiovascular and Haematological Disorders, vol. 3, no. 2, pp. 155–185, 2003. View at Publisher · View at Google Scholar · View at Scopus
- D. S. Wishart, C. Knox, A. C. Guo et al., “DrugBank: a knowledgebase for drugs, drug actions and drug targets,” Nucleic Acids Research, vol. 36, no. 1, pp. D901–D906, 2008. View at Publisher · View at Google Scholar · View at Scopus
- X. Q. Xie and J. Z. Chen, “Data mining a small molecule drug screening representative subset from NIH PubChem,” Journal of Chemical Information and Modeling, vol. 48, no. 3, pp. 465–475, 2008. View at Publisher · View at Google Scholar · View at Scopus
- T. S. Keshava Prasad, R. Goel, K. Kandasamy et al., “Human protein reference database—2009 update,” Nucleic Acids Research, vol. 37, no. 1, pp. D767–D772, 2009. View at Publisher · View at Google Scholar · View at Scopus
- G. D. Bader, D. Betel, and C. W. V. Hogue, “BIND: the biomolecular interaction network database,” Nucleic Acids Research, vol. 31, no. 1, pp. 248–250, 2003. View at Publisher · View at Google Scholar · View at Scopus
- S. Kerrien, B. Aranda, L. Breuza et al., “The IntAct molecular interaction database in 2012,” Nucleic Acids Research, vol. 40, no. D1, pp. D841–D846, 2012. View at Publisher · View at Google Scholar
- A. Ceol, A. Chatr Aryamontri, L. Licata et al., “MINT, the molecular interaction database: 2009 update,” Nucleic Acids Research, vol. 38, no. 1, Article ID gkp983, pp. D532–D539, 2009. View at Publisher · View at Google Scholar · View at Scopus
- K. R. Brown and I. Jurisica, “Online predicted human interaction database,” Bioinformatics, vol. 21, no. 9, pp. 2076–2082, 2005. View at Publisher · View at Google Scholar · View at Scopus
- D. W. Huang, B. T. Sherman, and R. A. Lempicki, “Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources,” Nature Protocols, vol. 4, no. 1, pp. 44–57, 2009. View at Publisher · View at Google Scholar · View at Scopus
- G. M. Morris, D. S. Goodsell, R. S. Halliday et al., “Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function,” Journal of Computational Chemistry, vol. 19, no. 14, pp. 1639–1662, 1998. View at Scopus
- J. C. Yeh, T. Cindrova-Davies, M. Belleri et al., “The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo,” Angiogenesis, vol. 14, no. 2, pp. 187–197, 2011. View at Publisher · View at Google Scholar · View at Scopus
- E. Zamir and P. I. H. Bastiaens, “Reverse engineering intracellular biochemical networks,” Nature Chemical Biology, vol. 4, no. 11, pp. 643–647, 2008. View at Publisher · View at Google Scholar · View at Scopus
- T. W. Corson and C. M. Crews, “Molecular understanding and modern application of traditional medicines: triumphs and trials,” Cell, vol. 130, no. 5, pp. 769–774, 2007. View at Publisher · View at Google Scholar · View at Scopus
- U. Rix and G. Superti-Furga, “Target profiling of small molecules by chemical proteomics,” Nature Chemical Biology, vol. 5, no. 9, pp. 616–624, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. A. Canny, Y. Cruz, M. R. Southern, and P. R. Griffin, “PubChem promiscuity: a web resource for gathering compound promiscuity data from PubChem,” Bioinformatics, vol. 28, no. 1, Article ID Article numberbtr622, pp. 140–141, 2012. View at Publisher · View at Google Scholar
- K. W. Lee, A. M. Bode, and Z. Dong, “Molecular targets of phytochemicals for cancer prevention,” Nature Reviews Cancer, vol. 11, no. 3, pp. 211–218, 2011. View at Publisher · View at Google Scholar · View at Scopus
- F. Y. Tang and M. Meydani, “Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production,” Nutrition and Cancer, vol. 41, no. 1-2, pp. 119–125, 2001. View at Scopus
- A. S. Chung and N. Ferrara, “Targeting the tumor microenvironment with Src kinase inhibition,” Clinical Cancer Research, vol. 16, no. 3, pp. 775–777, 2010. View at Publisher · View at Google Scholar · View at Scopus
- G. J. Roboz, S. Dias, G. Lam et al., “Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis,” Blood, vol. 96, no. 4, pp. 1525–1530, 2000. View at Scopus
- F. L. Minnear, M. A. A. DeMichele, D. G. Moon, C. L. Rieder, and J. W. Fenton, “Isoproterenol reduces thrombin-induced pulmonary endothelial permeability in vitro,” American Journal of Physiology, vol. 257, no. 5, part 2, pp. H1613–H1623, 1989. View at Scopus
- D. L. Ou, Y. C. Shen, J. D. Liang et al., “Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma,” Clinical Cancer Research, vol. 15, no. 18, pp. 5820–5828, 2009. View at Publisher · View at Google Scholar · View at Scopus
- H. R. Pearce, N. Kalia, K. D. Bardhan, and N. J. Brown, “Effects of aspirin and indomethacin on endothelial cell proliferation in vitro,” Journal of Gastroenterology and Hepatology, vol. 18, no. 10, pp. 1180–1187, 2003. View at Publisher · View at Google Scholar · View at Scopus
- R. Nussinov, C. J. Tsai, and P. Csermely, “Allo-network drugs: harnessing allostery in cellular networks,” Trends in Pharmacological Sciences, vol. 32, pp. 686–693, 2011.