- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 283941, 10 pages
A Novel Porous Gelatin Composite Containing Naringin for Bone Repair
1Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Yunlin 64002, Taiwan
2School of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan
3Department of Biomedical Imaging and Radiological Science, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan
Received 12 September 2012; Revised 15 December 2012; Accepted 22 December 2012
Academic Editor: Chong-Zhi Wang
Copyright © 2013 Kuo-Yu Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. Ogose, N. Kondo, H. Umezu et al., “Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferion) in human bones,” Biomaterials, vol. 27, no. 8, pp. 1542–1549, 2006.
- B. S. Liu, C. H. Yao, Y. S. Chen, and S. H. Hsu, “In vitro evaluation of degradation and cytotoxicity of a novel composite as a bone substitute,” Journal of Biomedical Materials Research A, vol. 67, no. 4, pp. 1163–1169, 2003.
- C. H. Yao, B. S. Liu, S. H. Hsu, Y. S. Chen, and C. C. Tsai, “Biocompatibility and biodegradation of a bone composite containing tricalcium phosphate and genipin crosslinked gelatin,” Journal of Biomedical Materials Research A, vol. 69, no. 4, pp. 709–717, 2004.
- C. H. Yao, B. S. Liu, S. H. Hsu, and Y. S. Chen, “Calvarial bone response to a tricalcium phosphate-genipin crosslinked gelatin composite,” Biomaterials, vol. 26, no. 16, pp. 3065–3074, 2005.
- A. M. C. Barradas, H. Yuan, C. A. van Blitterswijk, and P. Habibovic, “Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms,” European Cells and Materials, vol. 21, pp. 407–429, 2011.
- G. Matsumoto, Y. Omi, E. Kubota et al., “Enhanced regeneration of critical bone defects using a biodegradable gelatin sponge and β-tricalcium phosphate with bone morphogenetic protein-2,” Journal of Biomaterials Applications, vol. 24, no. 4, pp. 327–342, 2009.
- G. C. Dong, M. C. Hueih, and C. H. Yao, “A novel bone substitute composite composed of tricalcium phosphate, gelatin and drynaria fortunei herbal extract,” Journal of Biomedical Materials Research A, vol. 84, no. 1, pp. 167–177, 2008.
- C. H. Yao, B. S. Liu, C. G. Liu, and Y. S. Chen, “Osteogenic potential using a malleable, biodegradable composite added traditional Chinese medicine: in vitro and in vivo evaluations,” The American Journal of Chinese Medicine, vol. 34, no. 5, pp. 873–886, 2006.
- C. H. Yao, H. M. Tsai, Y. S. Chen, and B. S. Liu, “Fabrication and evaluation of a new composite composed of tricalcium phosphate, gelatin, and Chinese medicine as a bone substitute,” Journal of Biomedical Materials Research B, vol. 75, no. 2, pp. 277–288, 2005.
- C. H. Yao, C. C. Tsai, Y. S. Chen et al., “Fabrication and evaluation of a new composite composed of tricalcium phosphate, gelatin and Chi-Li-Saan as a bone substitute,” The American Journal of Chinese Medicine, vol. 30, no. 4, pp. 471–482, 2002.
- R. W. K. Wong and A. B. M. Rabie, “Traditional Chinese medicines and bone formation—a review,” Journal of Oral and Maxillofacial Surgery, vol. 64, no. 5, pp. 828–837, 2006.
- T. Y. Hung, T. L. Chen, M. H. Liao et al., “Drynaria fortunei J. Sm. promotes osteoblast maturation by inducing differentiation-related gene expression and protecting against oxidative stress-induced apoptotic insults,” Journal of Ethnopharmacology, vol. 131, no. 1, pp. 70–77, 2010.
- X. L. Wang, N. L. Wang, Y. Zhang et al., “Effects of eleven flavonoids from the osteoprotective fraction of Drynaria fortunei (Kunze) J. Sm. on osteoblastic proliferation using an osteoblast-like cell line,” Chemical and Pharmaceutical Bulletin, vol. 56, no. 1, pp. 46–51, 2008.
- J. C. Jeong, J. W. Lee, C. H. Yoon et al., “Stimulative effects of Drynariae Rhizoma extracts on the proliferation and differentiation of osteoblastic MC3T3-E1 cells,” Journal of Ethnopharmacology, vol. 96, no. 3, pp. 489–495, 2005.
- J. C. Jeong, J. W. Lee, C. H. Yoon, H. M. Kim, and C. H. Kim, “Drynariae Rhizoma promotes osteoblast differentiation and mineralization in MC3T3-E1 cells through regulation of bone morphogenetic protein-2, alkaline phosphatase, type I collagen and collagenase-1,” Toxicology In Vitro, vol. 18, no. 6, pp. 829–834, 2004.
- J. S. Sun, C. Y. Lin, G. C. Dong et al., “The effect of Gu-Sui-Bu (Drynaria fortunei J. Sm) on bone cell activities,” Biomaterials, vol. 23, no. 16, pp. 3377–3385, 2002.
- V. Habauzit, S. M. Sacco, A. Gil-Izquierdo, et al., “Differential effects of two citrus flavanones on bone quality in senescent male rats in relation to their bioavailability and metabolism,” Bone, vol. 49, no. 5, pp. 1108–1116, 2011.
- Y. Lu, C. Zhang, P. Bucheli, and D. Wei, “Citrus flavonoids in fruit and taditional Chinese medicinal food ingredients in China,” Plant Foods for Human Nutrition, vol. 61, no. 2, pp. 57–65, 2006.
- J. A. Manthey and K. Grohmann, “Phenols in citrus peel byproducts. Concentrations of hydroxycinnamates and polymethoxylated flavones in citrus peel molasses,” Journal of Agricultural and Food Chemistry, vol. 49, no. 7, pp. 3268–3273, 2001.
- J. B. Wu, Y. C. Fong, H. Y. Tsai, Y. F. Chen, M. Tsuzuki, and C. H. Tang, “Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts,” European Journal of Pharmacology, vol. 588, no. 2-3, pp. 333–341, 2008.
- M. Wei, Z. Yang, P. Li, Y. Zhang, and W. C. Sse, “Anti-osteoporosis activity of naringin in the retinoic acid-induced osteoporosis model,” The American Journal of Chinese Medicine, vol. 35, no. 4, pp. 663–667, 2007.
- K. Mandadi, M. Ramirez, G. K. Jayaprakasha et al., “Citrus bioactive compounds improve bone quality and plasma antioxidant activity in orchidectomized rats,” Phytomedicine, vol. 16, no. 6-7, pp. 513–520, 2009.
- W. Y. Pang, X. L. Wang, S. K. Mok et al., “Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells,” British Journal of Pharmacology, vol. 159, no. 8, pp. 1693–1703, 2010.
- X. Zhou, P. Zhang, C. Zhang, and Z. Zhu, “Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model,” Journal of Orthopaedic Research, vol. 28, no. 4, pp. 451–456, 2010.
- C. Y. Lin, J. S. Sun, S. Y. Sheu, F. H. Lin, Y. J. Wang, and L. T. Chen, “The effect of Chinese medicine on bone cell activities,” The American Journal of Chinese Medicine, vol. 30, no. 2-3, pp. 271–285, 2002.
- T. Sato, I. Morita, and S. Murota, “Involvement of cholesterol in osteoclast-like cell formation via cellular fusion,” Bone, vol. 23, no. 2, pp. 135–140, 1998.
- N. Takahashi, T. Akatsu, N. Udagawa et al., “Osteoblastic cells are involved in osteoclast formation,” Endocrinology, vol. 123, no. 5, pp. 2600–2602, 1988.
- G. Ciapetti, L. Ambrosio, L. Savarino et al., “Osteoblast growth and function in porous poly ε-caprolactone matrices for bone repair: a preliminary study,” Biomaterials, vol. 24, no. 21, pp. 3815–3824, 2003.
- J. S. Sun and R. M. Chang, “Alveolar mononuclear cells can develop into multinucleated osteoclasts: an in vitro cell culture model,” Journal of Biomedical Materials Research, vol. 52, no. 1, pp. 142–147, 2000.
- R. W. K. Wong and A. B. M. Rabie, “Effect of naringin on bone cells,” Journal of Orthopaedic Research, vol. 24, no. 11, pp. 2045–2050, 2006.
- X. Wang, L. Zhen, G. Zhang, M. S. Wong, L. Qin, and X. Yao, “Osteogenic effects of flavonoid aglycones from an osteoprotective fraction of Drynaria fortunei—An in vitro efficacy study,” Phytomedicine, vol. 18, no. 10, pp. 868–872, 2011.
- P. Zhang, K. R. Dai, S. G. Yan et al., “Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell,” European Journal of Pharmacology, vol. 607, no. 1–3, pp. 1–5, 2009.
- J. P. Schmitz and J. O. Hollinger, “The critical size defect as an experimental model for craniomandibulofacial nonunions,” Clinical Orthopaedics and Related Research, vol. 205, pp. 299–308, 1986.
- R. W. K. Wong and A. B. M. Rabie, “Effect of naringin collagen graft on bone formation,” Biomaterials, vol. 27, no. 9, pp. 1824–1831, 2006.