Ellagic Acid Reduces Adipogenesis through Inhibition of Differentiation-Prevention of the Induction of Rb Phosphorylation in 3T3-L1 Adipocytes

<table>EA was added at different day of differentiation to check time window of EA action. Data shows that the inhibitory effect on lipid accumulation was diminished when the addition of EA was delayed to day 2 of differentiation. (a) Morphology data from Oil Red O staining data show that EA inhibition of adipogenesis takes place predominantly within the first 2 days. (b) The first 2-day inhibitory effect exerted by EA was further confirmed by changes in the expression of specific adipocyte marker expression: PPAR<i>γ</i> and aP2. <i>β</i>-actin loading as control. (c and d) Densitometric data are expressed of PPAR<i>γ</i> and aP2 as mean ± SD of 3 independent experiments. <svg height="13.95" id="M8" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to control (without EA treatment). </table>

Evidence-Based Complementary and Alternative Medicine

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Figure 3

Figure 3: Ellagic Acid Reduces Adipogenesis through Inhibition of Differentiation-Prevention of the Induction of Rb Phosphorylation in 3T3-L1 Adipocytes 

Figure 3 | Ellagic Acid Reduces Adipogenesis through Inhibition of Differentiation-Prevention of the Induction of Rb Phosphorylation in 3T3-L1 Adipocytes 