Immunomodulatory Activity of Lactococcus lactis A17 from Taiwan Fermented Cabbage in OVA-Sensitized BALB/c Mice
Figure 4
Effect of oral administration of live or heat-killed Lactococcus lactis A17 (A17) on cytokines production in OVA-sensitized mouse spleen cell culture. Mice were orally administered with 109 CFU of live A17 (A17-A) or heat-killed A17 (A17-H) from day 1 to day 28 with OVA sensitization during the second week. The healthy control (CON) and allergy control (OVA) mice were administered PBS orally. After sacrificing, mice spleens were removed, and spleen cells ( cells/mL) were cultured with OVA (50 μg/mL) for 2 days. The concentration of IL-2 (a), IFN-γ (b), IL-4 (c), and IL-10 (d) in the media was determined by ELISA. Each value represents the mean ± SD, . A difference between A17 groups and OVA group was considered statistically significant when (**).
