Effect of Xiaoyaosan Decoction on Learning and Memory Deficit in Rats Induced by Chronic Immobilization Stress
Figure 2
Effects of XYS on body weights and locomotor activity test. (a) After 1-week treatment, body weight gain of the CIS + saline group, and the CIS + rolipram group, the CIS + XYS group decreased markedly compared with that of the control group (). After 2-week treatment, body weight gain of the CIS + saline group, the CIS + rolipram group, and the CIS + XYS group increased compared with themselves after 1-week treatment. These differences were not significant. After 2-week treatment, body weight gain of the CIS + saline group, the CIS + rolipram group, and the CIS + XYS group decreased markedly compared with that of the control group (). Body weight gain of the CIS + XYS group increased compared with that of the CIS + saline group significantly (). After 3-week treatment, body weight gain of the CIS + saline group, the CIS + rolipram group, and the CIS + XYS group decreased markedly compared with that of the control group (). Body weight gain of the CIS + rolipram group and the CIS + XYS group increased compared with the CIS + saline group significantly (). (b) There is no significant difference between any two groups in four groups in locomotor activity, as assessed by line crossings and rears after stress on day 21. Values shown are means ± SD of ten rats per group. ** versus the control group. #, ## versus the CIS + saline group.
