Curative Effects of ZHENG-Based Fuzheng-Huayu Tablet on Hepatitis B Caused Cirrhosis Related to CYP1A2 Genetic Polymorphism

Table 7

Correlation between CYP1A2 genotype and ZHENG types in FZHY efficacy.

Genotypes	Excess ZHENG		𝑃^#	Deficiency-Excess ZHENG		𝑃^#	Deficiency ZHENG		𝑃^#
	Effective (%); 𝑛=39	Invalid (%); 𝑛=30		Effective (%); 𝑛=10	Invalid (%); 𝑛=11		Effective (%); 𝑛=18	Invalid (%); 𝑛=3
CYP1A2-5347
CC	27 (69.23)	20 (66.67)		8 (80.00)	8 (72.73)		14 (77.78)	2 (66.67)
CT	11 (28.21)	5 (16.67)	0.425	2 (20.00)	3 (27.27)	1.000	4 (22.22)	1 (33.33)	1.000
TT	0 (0)	2 (6.67)	—	0 (0)	0 (0)	—	0 (0)	0 (0)	—
CT + TT	11 (28.21)	7 (23.33)	0.788	2 (20.00)	3 (27.27)	1.000	4 (22.22)	1 (33.33)	1.000
CYP1A2-2964
GG	17 (43.59)	15 (50.00)		7 (70.00)	5 (45.45)		1 (5.56)	2 (66.67)
GA	19 (48.72)	7 (23.33)	0.119	3 (30.00)	3 (27.27)	1.000	12 (66.67)	1 (33.33)	0.071
AA	3 (7.69)	6 (20.00)	0.454	0 (0)	3 (27.27)	—	5 (27.78)	0 (0)	—
GA + AA	22 (56.41)	13 (43.33)	0.420	3 (30.00)	6 (54.55)	0.387	17 (94.44)	1 (33.33)	0.041
CYP1A2-733
CC	5 (12.82)	2 (6.67)		2 (20.00)	1 (9.09)		2 (11.11)	0 (0)
CA	14 (35.89)	13 (43.33)	0.426	6 (60.00)	4 (36.36)	1.000	8 (44.44)	2 (66.67)	—
AA	20 (51.28)	13 (43.33)	0.691	2 (20.00)	6 (54.55)	0.491	8 (44.44)	1 (33.33)	—
CA + AA	34 (87.18)	26 (86.67)	0.454	8 (80.00)	10 (90.91)	0.586	16 (88.88)	3 (100.00)	—

The bold font emphasizes the result was statistically significant (𝑃<0.05)