High-Frequency Ultrasound Imaging to Evaluate Liver Fibrosis Progression in Rats and Yi Guan Jian Herbal Therapeutic Effects

Figure 2

The normal lobular architecture with central veins and radiating hepatic cords was observed in normal control rats ((A), (a), (D), and (d)). Fatty degeneration, necrosis, the infiltration of inflammatory cells, and the apparent formation of fibrotic septa were present in the 2-week DMN-treated group ((B), (b), (E), and (e)) and 4-week DMN-treated group ((C), (c), (F), and (f)). Tissue stained with H&E and imaged at 100x ((A), (B), and (C)) or 400x ((a), (b), and (c)) magnifications. Tissue stained with Masson’s trichrome and imaged at 100x ((D), (E), and (F)) or 400x ((d), (e), and (f)) magnifications.