High-Frequency Ultrasound Imaging to Evaluate Liver Fibrosis Progression in Rats and Yi Guan Jian Herbal Therapeutic Effects

Table 2

Ultrasound characteristics (40 MHz) of fibrosis in normal liver, 2-week DMN-treated fibrotic liver, and 4-week DMN-treated fibrotic liver.

Treatment	Parenchymal echotexture	Spleen size	Ascites	Surface or margin	Vasculature	Sum	Average^†
Normal control	0	0	0	0	0	0
	0	0	0	0	0	0
	0	0	0	0	0	0	0
	0	0	0	0	0	0
	0	0	0	0	0	0
DMN-induced fibrosis (2 wk)	1	0	0	0	0	1
	0	0	0	0	1	1
	1	0	0	0	0	1	1.6 ± 0.9*
	1	0	1	0	0	2
	1	1	0	0	1	3
DMN-induced fibrosis (4 wk)/PBS (2 wk)	2	1	1	1	2	7
	2	1	1	0	2	6
	2	1	0	1	2	6	6.2 ± 0.8**
	2	1	1	1	2	7
	1	1	0	1	2	5
DMN-induced fibrosis (4 wk)/YGJ (2 wk)	0	0	1	1	1	3
	0	0	1	0	1	2
	1	1	0	1	1	4	2.8 ± 0.8^*,#
	0	1	1	0	0	2
	1	1	0	0	1	3

†Each value represents the mean ± SEM of five rats.
^∗𝑃 < 0.05, **P < 0.01 versus normal control.
^#P < 0.05 versus DMN-induced fibrosis/PBS group.