Quercetin Preserves β-Cell Mass and Function in Fructose-Induced Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation

Figure 6

Effects of quercetin on the reduced phosphorylation of Jak2-Stat3 pathway (a) and the increased expression of Socs3 (b) in fructose-treated INS-1 β-cells. INS-1 β-cells were treated with 1 mM fructose in the absence or presence of 5, 10, and 20 μM quercetin for 24 h. Data were presented as the mean ± SEM of three to six independent experiments. ^#𝑃<0.05 and ^##𝑃<0.01 relative to untreated control cells; *𝑃<0.05 and **𝑃<0.01 relative to fructose-treated vehicle cells.

(a)

(b)