Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity

Table 2

Antileishmanial activity, cytotoxicity, and selective index found for the ethyl acetate extract of S. pseudoquina, quercetin 3-methyl ether, and strychnobiflavone.

Compounds	IC^a50	CC^b50	RBC^c50	SI^d
Ethyl acetate extract (μg/mL)	24.9±5.2	257.9±35.9	180.8±9.9	10.4
Quercetin 3-methyl ether (μM)	8.1±1.5	199.0±25.9	155.0±33.2	24.6
Strychnobiflavone (μM)	3.2±0.2	125±4.5	209.6±2.5	39.6
AmpB (μM)	0.1±0.13	0.8±0.2	ND^e	9.9

The results are expressed as medium ± standard deviation. ^aValue of inhibitory concentration of 50% of promastigotes of L. amazonensis. ^bValue of inhibitory concentration of 50% of murine macrophages. ^cValue of 50% of human red blood cell lysis. ^dSelectivity Index (ratio between CC₅₀ and IC₅₀). ^eNot Done. AmpB (amphotericin B) was used as a control drug. Values are the average of four independent experiments, which presented similar results.