Evidence of Antidepressive Effects of a Wakan-yaku, Hochuekkito, in Depression Model Mice with Learned-Helplessness Behavior
Figure 3
Effects of Hochuekkito and desipramine in the LH behavior test using depressive conditioned mice, non-LH mice and naïve control mice. The animals, except for naïve control (), received inescapable footshock once a day for 3 consecutive days. The avoidance test was performed on day 4 and 18 under escapable conditions. One g/kg/day Hochuekkito (▲), 5 g/kg/day Hochuekkito (■), 10 mg/kg/day desipramine (◯) or water as a vehicle () was p.o. administered in depressive conditioned mice once daily for 14 days from day 5. Water was p.o. administered also in non-LH condition (◆) and in naïve control (). The avoidance test on day 18 was conducted 60 min after the last drug administration. The data are expressed as the mean ± S.E.M. (per group). Significance: *versus vehicle-treated mice on day 18 () (two-way repeated ANOVA followed by the Student-Newman-Keuls test).
