Research Article
Effect of the African Traditional Medicine, Sutherlandia frutescens, on the Bioavailability of the Antiretroviral Protease Inhibitor, Atazanavir
Table 1
Non-compartmental and statistical analysis of PK parameters of ATV.
| | Pharmacokinetic parameter | Phase I
(ATV alone)
Arithmetic mean
(CV%) | Phase II
(ATV + SF)
Arithmetic mean
(CV%) | Phase II/Phase I
Geometric mean ratio
(90% CI) |
| | AUC0–24 (g/mL·hour) | 13.0
(50.3) | 10.0
(38.6) | 0.801
(0.634–1.01) | | (g/mL) | 3.17
(30.3) | 2.59
(43.6) | 0.783
(0.609–1.00) | | (hours) | 2.71
(26.7) | 2.67
(33.3) | N/A | | (hours) | 3.77
(39.5) | 3.82
(35.1) | N/A | |
(hour−1) | 0.205
(31.2) | 0.200
(30.9) | N/A |
|
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