Research Article

Cytotoxicity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Table 1

Korean plants with cytotoxic activity.

Plants (and family)Traditional usesPart usedPreviously reported activity of the plantReported chemical constituents

Alnus  japonica  Steudel (Betulaceae)In oriental traditional medicine as remedies for fever, hemorrhage, diarrhea, and alcoholism [43]Stems-stem barkHepatoprotective and antioxidant activities [44], antiviral activity against the influenza virus [45]1,7-Bis-(3,4-dihydroxyphenyl)-3-hydroxyheptane-5-O-β-D-xylopyranoside; 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-β-D-glucopyranosyl(1→3)-β-D-xylopyranoside; 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-β-D-apiofuranosyl(1→6)-β-D-glucopyranoside; 1,7-bis-(3,4-dihydroxyphenyl)-heptane-5-O-β-D-glucopyranoside; 1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxylheptane; 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-β-D-glucopyranoside; oregonin; hirsutanonol; hirsutenone; platyphylloside [44]; tannins (alnusjaponins A and B); 5-O-galloyl-(−)-shikimic acid, 2,3-(S)-hexahydroxydiphenoyl-D-glucose, 4,6-di-O-galloyl-D-glucose, 1,4-di-O-galloyl-β-D-glucose, 4,6-(S)-valoneoyl-D-glucose; strictinin; gemin D; pedunculagin; praecoxin A; flosin A; stachyurin; casuarinin [46], lupeol; betulin; betulinic aldehyde; 3-acetoxybetulinic aldehyde, β-sitosterol [45]

Camellia japonica L.  (Theaceae)Cosmetic protectant to keep the skin and hair healthy and as a soothing agent [47]FruitsAntibacterial activity [48], inhibitor of human immunodeficiency virus type 1 protease [49], Epstein-Barr virus inhibitor [50], antimetastasis activity [51], antioxidant activity [52, 53], inhibitor of human type I procollagen production [54], and antiallergic responses [55], anti-inflammatory [47]3β,18β-dihydroxy-28-norolean-12-en-16-one; 18β-hydroxy-28-norolean-12-ene-3,16-dione; camelliagenin A, B, and C [56], camellenodiol 3-O-β-D-galactopyranosyl(1→2)[β-D-xylopyranosyl(1→2)-β-D-galactopyranosyl(1→3)]-β-D-glucuronopyranoside; camellenodiol 3-O-4′′-O-acetyl-β-D-galactopyranosyl(1→2)[β-D-xylopyranosyl(1→2)-β-D-galactopyranosyl(1→3)]-β-D-glucuronopyranoside; camellenodiol 3-O-(β-D-galactopyranosyl(1→2)[β-D-xylopyranosyl(1→2)-β-D-galactopyranosyl(1→3)]-6′-methoxy-β-D-glucuronopyranoside; maragenin II 3-O-(β-D-galactopyranosyl(1→2)[β-D-xylopyranosyl(1→2)-β-D-galactopyranosyl(1→3)]-6′-methoxy-β-D-glucuronopyranoside, camellioside A; camellioside B [57]

Isodon japonicus  (Burman f.) H. Hara (Labiatae)Antibacterial, anti-inflammation, and anthelmintic [58]Whole plantCytotoxicity on K562 human leukemia cells and immunomodulatory activity [16], antibacterial activity for plant constituents [59] Isadonol; epinodosin; sodoponin; epinodosinol [60, 61]; epinodosin; oridonin; taihangjaponicain A; lushanrubescensin J; bisjaponins A and B [58]; isodonal, trichodonin; nodosin; enmein; oridonin; enmein-3-acetate [59]

Lycoris  radiata  (L'Her.) Herbert  (Amaryllidaceae)Laryngeal trouble, furuncle, carbuncle, suppurative wounds [62]Leaves, underground partsCytotoxicity against B16F10 melanoma cells [17]Different types of alkaloids (crinine-type; galanthamine-type; lycorine-type homolycorine-type; tazettine-type; narciclasine-type; and lycorine-type alkaloids); trisphaeridine; galanthine; bicolorine; 11-hydroxyvittatine; 8-O-demethymaritidine;O-demethylgalanthamine; O-demethyllycoramine [63]

Meliosma  oldhamii  Miq. ex. Maxim. (Sabiaceae)Liver ailments [64]Stems-stem barkLow Cholinesterase inhibition (12–19% at 5 mg/mL) [65], moderate alpha glucosidase activity [64]

Myrica  rubra  Sieb. and Zucc. (Myricaceae)Diarrhea; gastroenteritis in China [66]Stems-stem barkAntioxidant activity [67]; anti-influenza virus activity [68]Taraxerone; taraxerol; myricadiol; sitosterol; 28-hydroxy-D-friedoolean-14-en-3-one (); myricanol 5-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranoside; myricanol 5-O-α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside; isomyricanone [69]; cyanidin-3-O-glucoside; myricetin; quercetin-3-O-rutinoside [67]

Rubus  corchorifolius  L. f. (Rosaceae)Stomachache, diarrhea, and dysentery [18]Whole plantAntioxidant activity of essential oil [70]Ent-kauran-3β, 16β, 17, 19-tetrol; ent-2-carbonyl-16β-hydroxy-kauran-17β-D-glucoside [18]; rubusin A; quercetin; kaempferol [25]

Sageretia  theezans  (L.) Brongn  (Rhamnaceae)Tea materials [71]Leaves, StemsAntioxidant activity [72]7-O-methylmearnsitrin; myricetrin, kaempferol 3-O-α-L-rhamnopyranoside, europetin 3-O-α-L-rhamnoside, and 7-O-methyl quercetin 3-O-alpha-L-rhamnopyranoside; 7-O-methylmearnsetin 3-O-rhamnoside [71, 72]

Sedum  middendorffianum Maxim. (Crassulaceae)Whole plantkaempferol; quercetin; myricetin; arbutin [24]

Sedum  takesimense  Nakai (Crassulaceae)Whole plantAntioxidant activities [26]Ferulic acid; caffeic acid; gallic acid; methyl gallate; myricetin; quercetin; luteolin; rhodalin; rhodalidin; luteolin-7-O-β-D-glucoside; arbutin; 1-(4-hydroxyphenyl)-2-(3,5-dihydroxyphenyl)-2-hydroxyethanone; gossypetin-8-O-β-D-xylopyranoside; 2,6-di-O-galloylarbutin [26]

Sorbaria  sorbifolia  (L.) A. Br. var.  stellipila  MAX.  (Rosaceae)StemsAntioxidant activities, cytotoxicity [73, 74]Sutherlandin-5-trans-p-coumarate; cardiosdiospermin-5-(4-hydroxy) benzoate [75]; noreugenin; wogonin; 5,7,3′,4′-tetrahydroxy-3-methoxyflavone; protocatechuic acid; benzoic acid; emodin; daucosterol [76]; 5,2′,4′-trihydroxy-6,7,5′-trimethoxyflavone; succinic acid; p-hydroxybenzoic acid [77]

Vitis flexuosa  Thunb. (Vitaceae)Aerial partsFlexuosol A; gnetin A; (+)-epsilon-viniferin; vitisin A; hopeaphenol [78]

(—): not reported; the complete list of the tested plants is available in supplementary material.