Evidence-Based Complementary and Alternative Medicine

Research Article

Cytotoxicity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine

Table 4

Genes identified by standard or reverse COMPARE analyses, whose mRNA expression in a panel of 60 cell lines correlated with IC₅₀ values for deoxynarciclasine.


Pearson’s correlation coefficient	Experimental ID	Gene symbol	Name	Function

0.572	GC74997	SNAP25	Synaptosomal-associated protein, 25 kDa	Regulation of neurotransmitter release
0.56	GC32186	OPTN	Optineurin	Maintenance of membrane trafficking
0.557	GC52658	FAM116B	Family with sequence similarity 116, member B	Unknown
0.531	GC187393	ZDHHC7	Zinc finger, DHHCtype containing 7	Palmitoyltransferase
0.529	GC12575	CLEC9A	C-type lectin domain family 9, member A	Endocytic receptor for necrotic cells
0.528	GC188718	SNX6	Sorting nexin 6	Involved in intracellular trafficking
0.528	GC154565	RAB11FIP5	RAB11 family interacting protein 5 (class I)	Involved in protein trafficking
0.527	GC18484	NTAN 1	N-terminal asparagine amidase	Ubiquitin-dependent turnover of intracellular proteins
0.526	GC16433	DNAJC10	DnaJ (Hsp40) homolog, subfamily C, member 10	Endoplasmic reticulum cochaperone
0.524	GC10009	PCOLCE2	Procollagen C-endopeptidase enhancer 2	Binds to procollagens
0.524	GC45803	LMAN2L	Lectin, mannose-binding 2-like	Regulation of export from the endoplasmic reticulum
0.524	GC82947	NGDN	Neuroguidin, EIF4E binding protein	Involved in the translational repression
0.519	GC75800	SEC24D	SEC24 family, member D (S. cerevisiae)	Transport of ER-derived vesicles
0.517	GC90440	KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	Retention of luminal endoplasmic reticulum proteins
0.514	GC173264	GNA12	Guanine nucleotide binding protein (G protein) α12	Transducer in transmembrane signaling
0.512	GC170473	MYBL1	V-Myb myeloblastosis viral oncogene homolog (avian)-like 1	Transcriptional activator
0.512	GC175225	LPP	LIM domain containing preferred translocation partner in lipoma	Signal transduction from cell adhesion sites to the nucleus
0.511	GC14006	ITGB5	Integrin, β5	Receptor for fibronectin
0.509	GC150035	DCBLD2	Discoidin, CUB, and LCCL domain containing 2	Involved in tumor progression
0.508	GC73833	NCEH1	Neutral cholesterol ester hydrolase 1	Promotes tumor cell migration
0.507	GC177466	AHNAK	AHNAK nucleoprotein	Involved in neuronal cell differentiation
0.502	GC40315	ADAL	Adenosine deaminaselike	Putative nucleoside deaminase
0.502	GC28174	MPG	N-methylpurine-DNA glycosylase	Hydrolysis of alkylated DNA
0.501	GC18079	CR1	Complement component (3b/4b) receptor 1 (Knops blood group)	Mediates cellular binding of particles and immune complexes
−0.658	GC18354	ILF2	Interleukin enhancer binding factor 2, 45 kDa	Transcription
−0.608	GC44240	NDUFA2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8 kDa	Part of mitochondrial membrane respiratory chain
−0.605	GC65788	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	Involved in RNA replication
−0.589	GC43237	CWF19L1	CWF19-like 1, cell cycle control (S. pombe)	Cell cycle control
−0.572	GC174320	BCLAF1	BCL2-associated transcription factor 1	Death-promoting transcriptional repressor
−0.572	GC40779	LARS	Leucyl-tRNA synthetase	Editing of tRNA
−0.567	GC151509	FRAT2	Frequently rearranged in advanced T-cell lymphomas 2	Wnt signaling regulator
−0.561	GC175610	IK	IK cytokine, downregulator of HLA II	May bind to chromatin
−0.555	GC30213	SLN	Sarcolipin	Sarcoplasmic reticulum proteolipid
−0.553	GC162737	ANKHD2		Unknown
−0.552	GC17532	SFRS28		Unknown
−0.55	GC185046	SFRS1	Serine/arginine-rich splicing factor 1	Splicing regulator
−0.55	GC37292	FARSA	Phenylalanyl-tRNA synthetase, α subunit	Phenylalanine-tRNA ligase
−0.548	GC32318	MKI67	Antigen identified by monoclonal antibody Ki-67	Cell proliferation
−0.548	GC149101	MATR3	Matrin 3	Regulator of transcription
−0.547	GC150688	PSPC1	Paraspeckle component 1	Regulator of androgen receptor-mediated gene transcription
−0.546	GC80581	ZBTB11	Zinc finger and BTB domain containing 11	Regulator of transcription
−0.546	GC52470	MLF1IP	MLF1 interacting protein	Involved in mitotic progression
−0.545	GC81490	NUDT21	Nudix (nucleoside diphosphate linked moiety X)-type motif 21	Involved in pre-mRNA 3′-processing
−0.543	GC33504	DDX39	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A	Involved in pre-mRNA splicing
−0.543	GC35760	NDUGB8		Unknown
−0.539	GC36766	CHUK	Conserved helix-loop-helix ubiquitous kinase	Involved in NF-kappa-B signaling
−0.538	GC33463	POLD1	Polymerase (DNA directed), 1, catalytic subunit	DNA synthesis
−0.537	GC83208	SERBP1	SERPINE1 mRNA binding protein 1	Regulation of mRNA stability
−0.536	GC153558	CNOT8	CCR4-NOT transcription complex, subunit 8	Transcription factor
−0.535	GC17771	GOT1	Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	Involved in amino acid metabolism
−0.535	GC43091	NUDCD2	NudC domain containing 2	Unknown
−0.534	GC31949	HSPA9	Heat shock 70 kDa protein 9 (mortalin)	Control of cell proliferation and cellular aging
−0.533	GC91403	IKZF5	IKAROS family zinc finger 5 (Pegasus)	Transcriptional repressor
−0.533	GC31641	SF1	Splicing factor 1	Transcriptional repressor
−0.532	GC161453	KDM2B	Lysine (K)-specific demethylase 2B	Histone demethylase
−0.53	GC35520	EBP	CCAAT/enhancer binding protein (C/EBP), gamma	Transcription factor
−0.53	GC10226	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	Heme transport

Information on gene functions was taken from the OMIM database, NCI, USA, (http://www.ncbi.nlm.nih.gov/Omim/) and from the GeneCard database of the Weizmann Institute of Science, Rehovot, Israel (http://bioinfo.weizmann.ac.il/cards/index.html).