Antidiabetic Activity of Polysaccharides from Tuberous Root of Liriope spicata var. prolifera in KKAy Mice

Figure 6

Effect of polysaccharides on protein expression of InsR-α (a), IRS-1 (b), PI3K (c) and PPARγ (d) in liver tissues of KKAy mice. (a)–(d) Western blot analysis of InsR-α, IRS-1, PI3K, and PPARγ. Expression of InsR-α, IRS-1, PI3K, and PPARγ was assessed by western blot analysis. Western blot corrected by that of the protected β-actin band in each lane. Each protein is expressed as the intensity of band. Bands were quantified by densitometry. (A) Diabetic control obese KKAy mice; (B) obese KKAy mice treated with rosiglitazone; (C) normal control C57BL/6J mice; (D)-(E) Obese KKAy mice treated with TLSP (200; 100 mg·kg⁻¹·day⁻¹); (F)-(G) obese KKAy mice treated with LSP1 (200; 100 mg·kg⁻¹·day⁻¹); (H)-(I) obese KKAy mice treated with LSP2 (200; 100  mg·kg⁻¹·day⁻¹). Data were presented as mean ± SD (𝑛=7-8). *𝑃<0.05, **𝑃<0.01 versus diabetic control (vehicle treated).

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